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Differential expression of CD11c defines two types of tissue-resident macrophages with different origins in steady-state salivary glands
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Differential expression of CD11c defines two types of tissue-resident macrophages with different origins in steady-state salivary glands
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Journal Article
Differential expression of CD11c defines two types of tissue-resident macrophages with different origins in steady-state salivary glands
2022
Overview
Gland macrophages are primed for gland development and functions through interactions within their niche. However, the phenotype, ontogeny, and function of steady-state salivary gland (SG) macrophages remain unclear. We herein identified CD11c
+
and CD11c
−
subsets among CD64
+
macrophages in steady-state murine SGs. CD11c
−
macrophages were predominant in the SGs of embryonic and newborn mice and decreased with advancing age. CD11c
+
macrophages were rarely detected in the embryonic period, but rapidly expanded after birth. CD11c
+
, but not CD11c
−
, macrophage numbers decreased in mice treated with a CCR2 antagonist, suggesting that CD11c
+
macrophages accumulate from bone marrow-derived progenitors in a CCR2-dependent manner, whereas CD11c
−
macrophages were derived from embryonic progenitors in SGs. CD11c
+
and CD11c
−
macrophages strongly expressed colony-stimulating factor (CSF)-1 receptor, the injection of an anti-CSF-1 receptor blocking antibody markedly reduced both subsets, and SGs strongly expressed CSF-1, indicating the dependency of SG resident macrophage development on CSF-1. The phagocytic activity of SG macrophages was extremely weak; however, the gene expression profile of SG macrophages indicated that SG macrophages regulate gland development and functions in SGs. These results suggest that SG CD11c
+
and CD11c
−
macrophages are developed and instructed to perform SG-specific functions in steady-state SGs.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/80
/ Animals
/ Dendritic Cells - immunology
/ Embryos
/ Female
/ Gene Expression Regulation, Developmental - genetics
/ Humanities and Social Sciences
/ Macrophage colony-stimulating factor
/ Macrophage Colony-Stimulating Factor - metabolism
/ Male
/ Monocyte chemoattractant protein 1
/ Ontogeny
/ Salivary Glands - immunology
/ Salivary Glands - metabolism
/ Science
