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Subcortical electrophysiological activity is detectable with high-density EEG source imaging
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Subcortical electrophysiological activity is detectable with high-density EEG source imaging
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Journal Article
Subcortical electrophysiological activity is detectable with high-density EEG source imaging
2019
Overview
Subcortical neuronal activity is highly relevant for mediating communication in large-scale brain networks. While electroencephalographic (EEG) recordings provide appropriate temporal resolution and coverage to study whole brain dynamics, the feasibility to detect subcortical signals is a matter of debate. Here, we investigate if scalp EEG can detect and correctly localize signals recorded with intracranial electrodes placed in the centromedial thalamus, and in the nucleus accumbens. Externalization of deep brain stimulation (DBS) electrodes, placed in these regions, provides the unique opportunity to record subcortical activity simultaneously with high-density (256 channel) scalp EEG. In three patients during rest with eyes closed, we found significant correlation between alpha envelopes derived from intracranial and EEG source reconstructed signals. Highest correlation was found for source signals in close proximity to the actual recording sites, given by the DBS electrode locations. Therefore, we present direct evidence that scalp EEG indeed can sense subcortical signals.
Electroencephalography (EEG) allows the measurement of electrical signals associated with brain activity, but it is unclear if EEG can accurately measure subcortical activity. Here, the authors show that source dynamics, reconstructed from scalp EEG, correlate with activity recorded from human thalamus and nucleus accumbens.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/378
/ Brain
/ Deep Brain Stimulation - methods
/ Density
/ EEG
/ Electroencephalography - instrumentation
/ Electroencephalography - methods
/ Electrophysiological Phenomena
/ Humanities and Social Sciences
/ Humans
/ Intralaminar Thalamic Nuclei - diagnostic imaging
/ Intralaminar Thalamic Nuclei - physiology
/ Intralaminar Thalamic Nuclei - physiopathology
/ Nucleus Accumbens - diagnostic imaging
/ Nucleus Accumbens - physiology
/ Nucleus Accumbens - physiopathology
/ Obsessive-Compulsive Disorder - diagnostic imaging
/ Obsessive-Compulsive Disorder - physiopathology
/ Obsessive-Compulsive Disorder - therapy
/ Science
/ Thalamus
/ Tourette Syndrome - diagnostic imaging
