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Sensitive identification of neoantigens and cognate TCRs in human solid tumors

by Bassani-Sternberg, Michal , Schmidt, Julien , Chiffelle, Johanna , Nguyen-Ngoc, Tu , Coukos, George , Chong, Chloe , Gfeller, David , Irving, Melita , Zoete, Vincent , Arnaud, Marion , Genolet, Raphael , Bobisse, Sara , Navarro Rodrigo, Blanca , Guillaume, Philippe , Kandalaft, Lana E. , Magnin, Morgane , Harari, Alexandre , Speiser, Daniel E. , Huber, Florian , Baumgaertner, Petra , Stevenson, Brian J. , Perez, Marta A. S.

in 631/250/1619/554/1775 / 631/67/1059/2325 / 692/308/575 / Agriculture / Animals / Antigen (tumor-associated) / Antigens / Antigens, Neoplasm - genetics / Bioinformatics / Biomedical and Life Sciences / Biomedical Engineering/Biotechnology / Biomedicine / Biotechnology / Brief Communication / Cancer vaccines / CD8-Positive T-Lymphocytes / Humans / Life Sciences / Lymphocytes / Lymphocytes T / Lymphocytes, Tumor-Infiltrating / Mice / Neoantigens / Neoplasms - genetics / Neoplasms - therapy / Receptors, Antigen, T-Cell - genetics / Solid tumors / T cell receptors / T-Lymphocytes / Tumor-infiltrating lymphocytes / Tumors / Xenografts / Xenotransplantation

2022

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Sensitive identification of neoantigens and cognate TCRs in human solid tumors

2022

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2022

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Journal Article

Sensitive identification of neoantigens and cognate TCRs in human solid tumors

Bassani-Sternberg, Michal,

Schmidt, Julien,

Chiffelle, Johanna,

Nguyen-Ngoc, Tu,

Coukos, George,

Chong, Chloe,

Gfeller, David,

Irving, Melita,

Zoete, Vincent,

Arnaud, Marion,

Genolet, Raphael,

Bobisse, Sara,

Navarro Rodrigo, Blanca,

Guillaume, Philippe,

Kandalaft, Lana E.,

Magnin, Morgane,

Harari, Alexandre,

Speiser, Daniel E.,

Huber, Florian,

Baumgaertner, Petra,

Stevenson, Brian J.,

Perez, Marta A. S.

2022

Overview

The identification of patient-specific tumor antigens is complicated by the low frequency of T cells specific for each tumor antigen. Here we describe NeoScreen, a method that enables the sensitive identification of rare tumor (neo)antigens and of cognate T cell receptors (TCRs) expressed by tumor-infiltrating lymphocytes. T cells transduced with tumor antigen-specific TCRs identified by NeoScreen mediate regression of established tumors in patient-derived xenograft mice. NeoScreen helps identify rare tumor antigens for personalized cancer vaccines and T cell therapies.

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Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

631/250/1619/554/1775

/ 631/67/1059/2325

/ 692/308/575

/ Agriculture

/ Animals

/ Antigen (tumor-associated)

/ Antigens