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Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease
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Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease
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Journal Article
Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease
2021
Overview
Neutrophils play fundamental roles in innate immune response, shape adaptive immunity, and are a potentially causal cell type underpinning genetic associations with immune system traits and diseases. Here, we profile the binding of myeloid master regulator PU.1 in primary neutrophils across nearly a hundred volunteers. We show that variants associated with differential PU.1 binding underlie genetically-driven differences in cell count and susceptibility to autoimmune and inflammatory diseases. We integrate these results with other multi-individual genomic readouts, revealing coordinated effects of PU.1 binding variants on the local chromatin state, enhancer-promoter contacts and downstream gene expression, and providing a functional interpretation for 27 genes underlying immune traits. Collectively, these results demonstrate the functional role of PU.1 and its target enhancers in neutrophil transcriptional control and immune disease susceptibility.
PU.1 is a master regulator of myeloid development but its role in disease-relevant neutrophils is not well known. Here, the authors look at primary neutrophils from a human population and find that genetic variants affecting binding of PU.1 are associated with cell count and disease susceptibility.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45/43
/ 45/91
/ 49/39
/ Adult
/ Aged
/ Autoimmune Diseases - genetics
/ Autoimmune Diseases - immunology
/ Binding
/ Chromatin Immunoprecipitation Sequencing
/ Disease
/ Enhancer Elements, Genetic - genetics
/ Female
/ Gene Expression Regulation - immunology
/ Humanities and Social Sciences
/ Humans
/ Male
/ Promoter Regions, Genetic - genetics
/ Proto-Oncogene Proteins - metabolism
/ Quantitative Trait Loci - genetics
/ Quantitative Trait Loci - immunology
/ Science
