Asset Details
Do you wish to reserve the book?
Organ-specific, multimodal, wireless optoelectronics for high-throughput phenotyping of peripheral neural pathways
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Organ-specific, multimodal, wireless optoelectronics for high-throughput phenotyping of peripheral neural pathways
Do you wish to request the book?
Organ-specific, multimodal, wireless optoelectronics for high-throughput phenotyping of peripheral neural pathways
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Organ-specific, multimodal, wireless optoelectronics for high-throughput phenotyping of peripheral neural pathways
2021
Overview
The vagus nerve supports diverse autonomic functions and behaviors important for health and survival. To understand how specific components of the vagus contribute to behaviors and long-term physiological effects, it is critical to modulate their activity with anatomical specificity in awake, freely behaving conditions using reliable methods. Here, we introduce an organ-specific scalable, multimodal, wireless optoelectronic device for precise and chronic optogenetic manipulations in vivo. When combined with an advanced, coil-antenna system and a multiplexing strategy for powering 8 individual homecages using a single RF transmitter, the proposed wireless telemetry enables low cost, high-throughput, and precise functional mapping of peripheral neural circuits, including long-term behavioral and physiological measurements. Deployment of these technologies reveals an unexpected role for stomach, non-stretch vagal sensory fibers in suppressing appetite and demonstrates the durability of the miniature wireless device inside harsh gastric conditions.
Advances in wireless technologies have enabled internalisation of light sources, but organ specific illumination is challenging. Here, the authors present a durable, multimodal, wireless system enabling optogenetic stimulation of peripheral neurons within organs.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 82/80
/ Animals
/ Appetite
/ Behavior Observation Techniques - instrumentation
/ Calcitonin Gene-Related Peptide - genetics
/ Chemoreceptor Cells - physiology
/ Coils
/ Female
/ Fibers
/ High-Throughput Screening Assays - instrumentation
/ Humanities and Social Sciences
/ Male
/ Neural Pathways - physiology
/ Optogenetics - instrumentation
/ Organs
/ Remote Sensing Technology - instrumentation
/ Science
