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Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces
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Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces
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Journal Article
Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces
2018
Overview
Increasing concerns over the possible risks of nanotechnology necessitates breakthroughs in structure–activity relationship (SAR) analyses of engineered nanomaterials (ENMs) at nano-bio interfaces. However, current nano-SARs are often based on univariate assessments and fail to provide tiered views on ENM-induced bio-effects. Here we report a multi-hierarchical nano-SAR assessment for a representative ENM, Fe
2
O
3
, by metabolomics and proteomics analyses. The established nano-SAR profile allows the visualizing of the contributions of seven basic properties of Fe
2
O
3
to its diverse bio-effects. For instance, although surface reactivity is responsible for Fe
2
O
3
-induced cell migration, the inflammatory effects of Fe
2
O
3
are determined by aspect ratio (nanorods) or surface reactivity (nanoplates). These nano-SARs are examined in THP-1 cells and animal lungs, which allow us to decipher the detailed mechanisms including NLRP3 inflammasome pathway and monocyte chemoattractant protein-1-dependent signaling. This study provides more insights for nano-SARs, and may facilitate the tailored design of ENMs to render them desired bio-effects.
Understanding nano-bio interactions is key to optimizing the biocompatible design of nanomaterials. Here, the authors combine proteomic and metabolomics studies to evaluate the effect of varying physicochemical properties of iron oxide nanoparticles in macrophage-like cells and mouse lungs.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 147/143
/ 64/60
/ 82/16
/ 82/58
/ Animals
/ Cell Movement - drug effects
/ Ferric Compounds - chemistry
/ Ferric Compounds - pharmacology
/ Humanities and Social Sciences
/ Humans
/ Lungs
/ Monocyte chemoattractant protein
/ Monocyte chemoattractant protein 1
/ Nanorods
/ NLR Family, Pyrin Domain-Containing 3 Protein - metabolism
/ Proteins
/ Science
/ Structure-Activity Relationship
