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Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis
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Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis
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Journal Article
Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis
2021
Overview
In healthy joints, synovial fibroblasts (SFs) provide the microenvironment required to mediate homeostasis, but these cells adopt a pathological function in rheumatoid arthritis (RA). Carbohydrates (glycans) on cell surfaces are fundamental regulators of the interactions between stromal and immune cells, but little is known about the role of the SF glycome in joint inflammation. Here we study stromal guided pathophysiology by mapping SFs glycosylation pathways. Combining transcriptomic and glycomic analysis, we show that transformation of fibroblasts into pro-inflammatory cells is associated with glycan remodeling, a process that involves TNF-dependent inhibition of the glycosyltransferase ST6Gal1 and α2-6 sialylation. SF sialylation correlates with distinct functional subsets in murine experimental arthritis and remission stages in human RA. We propose that pro-inflammatory cytokines remodel the SF-glycome, converting the synovium into an under-sialylated and highly pro-inflammatory microenvironment. These results highlight the importance of glycosylation in stromal immunology and joint inflammation.
Dysregulation of synovial fibroblasts is thought to be an important step in the pathogenesis of rheumatoid arthritis. Here the authors implicate α2-6 sialylation in this process by studying the glycome of these cells in patients and in a mouse model of inflammatory joint disease.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/106
/ 13/21
/ 13/31
/ 14/63
/ 38/77
/ 38/91
/ 49/31
/ 64/60
/ Animals
/ Arthritis, Experimental - pathology
/ Arthritis, Rheumatoid - immunology
/ Arthritis, Rheumatoid - metabolism
/ Arthritis, Rheumatoid - pathology
/ beta-D-Galactoside alpha 2-6-Sialyltransferase
/ Glycan
/ Humanities and Social Sciences
/ Humans
/ Male
/ Metabolic Networks and Pathways
/ Mice
/ RNA-Seq
/ Science
/ Sialyltransferases - genetics
/ Sialyltransferases - metabolism
/ Synovial Membrane - immunology
/ Synovial Membrane - metabolism
/ Synovial Membrane - pathology
/ Synovium
