Asset Details
Do you wish to reserve the book?
Western diet leads to aging-related tumorigenesis via activation of the inflammatory, UPR, and EMT pathways
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Western diet leads to aging-related tumorigenesis via activation of the inflammatory, UPR, and EMT pathways
Do you wish to request the book?
Western diet leads to aging-related tumorigenesis via activation of the inflammatory, UPR, and EMT pathways
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Western diet leads to aging-related tumorigenesis via activation of the inflammatory, UPR, and EMT pathways
2021
Overview
Among the principal causative factors for the development of complications related to aging is a diet rich in fats and sugars, also known as the Western diet. This diet advocates numerous changes that might increase the susceptibility to initiate cancer and/or to create a tissue microenvironment more conducive to the growth of malignant cells, thus favoring the progression of cancer and metastasis. Hypercaloric diets in general lead to oxidative stress generating reactive oxygen species and induce endoplasmic reticulum stress. Our results demonstrate that mice bearing tumors fed with a Western diet presented bigger tumor mass with increased insulin sensitivity in these tissues. Several markers of insulin signaling, such as AKT phosphorylation and mTOR pathway, are promoted in tumors of Western diet-fed animals. This process is associated with increased macrophage infiltration, activation of unfolded protein response pathway, and initiation of epithelial–mesenchymal transition (EMT) process in these tumor tissues. Summing up, we propose that the Western diet accelerates the aging-related processes favoring tumor development.
Publisher
Nature Publishing Group UK,Springer Nature B.V,Nature Publishing Group
Subject
/ 38/77
/ 64/60
/ 82/29
/ 82/80
/ 96/21
/ 96/95
/ Aging
/ Animals
/ Biomedical and Life Sciences
/ Diet
/ Diet, High-Fat - adverse effects
/ Diet, Western - adverse effects
/ Epithelial-Mesenchymal Transition - drug effects
/ Female
/ Gene Expression Regulation, Neoplastic
/ Inflammation Mediators - metabolism
/ Insulin
/ Melanoma, Experimental - genetics
/ Melanoma, Experimental - immunology
/ Melanoma, Experimental - metabolism
/ Melanoma, Experimental - pathology
/ Mice
/ Receptor, Insulin - genetics
/ Receptor, Insulin - metabolism
/ Stearoyl-CoA Desaturase - genetics
/ Stearoyl-CoA Desaturase - metabolism
/ Tumors
