Asset Details
Do you wish to reserve the book?
Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936
Do you wish to request the book?
Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936
2019
Overview
Although plasma proteins may serve as markers of neurological disease risk, the molecular mechanisms responsible for inter-individual variation in plasma protein levels are poorly understood. Therefore, we conduct genome- and epigenome-wide association studies on the levels of 92 neurological proteins to identify genetic and epigenetic loci associated with their plasma concentrations (n = 750 healthy older adults). We identify 41 independent genome-wide significant (P < 5.4 × 10
−10
) loci for 33 proteins and 26 epigenome-wide significant (P < 3.9 × 10
−10
) sites associated with the levels of 9 proteins. Using this information, we identify biological pathways in which putative neurological biomarkers are implicated (neurological, immunological and extracellular matrix metabolic pathways). We also observe causal relationships (by Mendelian randomisation analysis) between changes in gene expression (DRAXIN, MDGA1 and KYNU), or DNA methylation profiles (MATN3, MDGA1 and NEP), and altered plasma protein levels. Together, this may help inform causal relationships between biomarkers and neurological diseases.
Plasma levels of neurological proteins have the potential to serve as biomarkers for neurological conditions. Here, Hillary et al. perform genome- and epigenome-wide association studies for 92 neurological proteins and identify 41 genomic loci for 33 proteins and 26 CpG sites for 9 proteins.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/378
/ Aged
/ DNA
/ Epigenesis, Genetic - genetics
/ Female
/ Genome-Wide Association Study
/ Genomes
/ Humanities and Social Sciences
/ Humans
/ Loci
/ Male
/ Nervous System Diseases - blood
/ Nervous System Diseases - genetics
/ Proteins
/ Quantitative Trait Loci - genetics
/ Science
/ Scotland
