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MqsR toxin as a biotechnological tool for plant pathogen bacterial control
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Journal Article
MqsR toxin as a biotechnological tool for plant pathogen bacterial control
2022
Overview
Type II toxin-antitoxin (TA) systems are widespread in bacteria and are involved in important cell features, such as cell growth inhibition and antimicrobial tolerance, through the induction of persister cells. Overall, these characteristics are associated with bacterial survival under stress conditions and represent a significant genetic mechanism to be explored for antibacterial molecules. We verified that even though
Xylella fastidiosa
and
Xanthomonas citri
subsp.
citri
share closely related genomes, they have different Type II TA system contents. One important difference is the absence of
mqsRA
in
X. citri
. The toxin component of this TA system has been shown to inhibit the growth of
X. fastidiosa
. Thus, the absence of
mqsRA
in
X. citri
led us to explore the possibility of using the MqsR toxin to impair
X. citri
growth. We purified MqsR and confirmed that the toxin was able to inhibit
X. citri
. Subsequently, transgenic citrus plants producing MqsR showed a significant reduction in citrus canker and citrus variegated chlorosis symptoms caused, respectively, by
X. citri
and
X. fastidiosa
. This study demonstrates that the use of toxins from TA systems is a promising strategy to be explored aiming bacterial control.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Anti-Bacterial Agents - pharmacology
/ Bacteria
/ Bacterial Toxins - pharmacology
/ Biofilms
/ Canker
/ Disease Resistance - genetics
/ Escherichia coli Proteins - genetics
/ Genomes
/ Humanities and Social Sciences
/ Plant Diseases - microbiology
/ Plants, Genetically Modified - genetics
/ Science
/ Toxins
