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Dietary cis-9, trans-11-conjugated linoleic acid reduces amyloid β-protein accumulation and upregulates anti-inflammatory cytokines in an Alzheimer’s disease mouse model
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Dietary cis-9, trans-11-conjugated linoleic acid reduces amyloid β-protein accumulation and upregulates anti-inflammatory cytokines in an Alzheimer’s disease mouse model
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Journal Article
Dietary cis-9, trans-11-conjugated linoleic acid reduces amyloid β-protein accumulation and upregulates anti-inflammatory cytokines in an Alzheimer’s disease mouse model
2021
Overview
Conjugated linoleic acid (CLA) is an isomer of linoleic acid (LA). The predominant dietary CLA is
cis
-9,
trans
-11-CLA (
c
-9,
t
-11-CLA), which constitutes up to ~ 90% of total CLA and is thought to be responsible for the positive health benefits associated with CLA. However, the effects of
c
-9,
t
-11-CLA on Alzheimer’s disease (AD) remain to be elucidated. In this study, we investigated the effect of dietary intake of
c
-9,
t
-11-CLA on the pathogenesis of an AD mouse model. We found that
c
-9,
t
-11-CLA diet-fed AD model mice significantly exhibited (1) a decrease in amyloid-β protein (Aβ) levels in the hippocampus, (2) an increase in the number of microglia, and (3) an increase in the number of astrocytes expressing the anti-inflammatory cytokines, interleukin-10 and 19 (IL-10, IL-19), with no change in the total number of astrocytes. In addition, liquid chromatography–tandem mass spectrometry (LC–MS/MS) and gas chromatographic analysis revealed that the levels of lysophosphatidylcholine (LPC) containing
c
-9,
t
-11-CLA (CLA-LPC) and free
c
-9,
t
-11-CLA were significantly increased in the brain of
c
-9,
t
-11-CLA diet-fed mice. Thus, dietary
c
-9,
t
-11-CLA entered the brain and appeared to exhibit beneficial effects on AD, including a decrease in Aβ levels and suppression of inflammation.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/80
/ 692/308
/ 692/420
/ 692/699
/ Alzheimer Disease - diet therapy
/ Alzheimer Disease - metabolism
/ Alzheimer Disease - pathology
/ Amyloid
/ Amyloid beta-Peptides - analysis
/ Amyloid beta-Peptides - metabolism
/ Animals
/ Diet
/ Dietary Fats, Unsaturated - therapeutic use
/ Humanities and Social Sciences
/ Humans
/ Linoleic Acids, Conjugated - therapeutic use
/ Mice
/ Science
