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The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis
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The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis
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Journal Article
The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis
2018
Overview
Tubulogenesis is essential for the formation and function of internal organs. One such organ is the trachea, which allows gas exchange between the external environment and the lungs. However, the cellular and molecular mechanisms underlying tracheal tube development remain poorly understood. Here, we show that the potassium channel KCNJ13 is a critical modulator of tracheal tubulogenesis. We identify
Kcnj13
in an ethylnitrosourea forward genetic screen for regulators of mouse respiratory organ development.
Kcnj13
mutants exhibit a shorter trachea as well as defective smooth muscle (SM) cell alignment and polarity. KCNJ13 is essential to maintain ion homeostasis in tracheal SM cells, which is required for actin polymerization. This process appears to be mediated, at least in part, through activation of the actin regulator AKT, as pharmacological increase of AKT phosphorylation ameliorates the
Kcnj13-
mutant trachea phenotypes. These results provide insight into the role of ion homeostasis in cytoskeletal organization during tubulogenesis.
Tubulogenesis is required for the formation of many internal structures including the trachea. Here, the authors show that the potassium channel KCNJ13 regulates tracheal tube formation, with shorter tracheas forming in mutant mice due in part to changes in actin organization in tracheal smooth muscle cells.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/19
/ 38/70
/ 38/77
/ 45
/ 45/23
/ 64/60
/ 82/51
/ 82/80
/ Actin
/ Actin Cytoskeleton - metabolism
/ Actin Cytoskeleton - ultrastructure
/ Animals
/ Female
/ Gene Expression Regulation, Developmental
/ Humanities and Social Sciences
/ Lungs
/ Muscles
/ Myocytes, Smooth Muscle - cytology
/ Myocytes, Smooth Muscle - metabolism
/ Organs
/ Polarity
/ Potassium Channels, Inwardly Rectifying - deficiency
/ Potassium Channels, Inwardly Rectifying - genetics
/ Proto-Oncogene Proteins c-akt - genetics
/ Proto-Oncogene Proteins c-akt - metabolism
/ Science
/ Trachea
