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Superior Colliculus to VTA pathway controls orienting response and influences social interaction in mice
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Superior Colliculus to VTA pathway controls orienting response and influences social interaction in mice
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Superior Colliculus to VTA pathway controls orienting response and influences social interaction in mice
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Journal Article
Superior Colliculus to VTA pathway controls orienting response and influences social interaction in mice
2022
Overview
Social behaviours characterize cooperative, mutualistic, aggressive or parental interactions that occur among conspecifics. Although the Ventral Tegmental Area (VTA) has been identified as a key substrate for social behaviours, the input and output pathways dedicated to specific aspects of conspecific interaction remain understudied. Here, in male mice, we investigated the activity and function of two distinct VTA inputs from superior colliculus (SC-VTA) and medial prefrontal cortex (mPFC-VTA). We observed that SC-VTA neurons display social interaction anticipatory calcium activity, which correlates with orienting responses towards an unfamiliar conspecific. In contrast, mPFC-VTA neuron population activity increases after initiation of the social contact. While protracted phasic stimulation of SC-VTA pathway promotes head/body movements and decreases social interaction, inhibition of this pathway increases social interaction. Here, we found that SC afferents mainly target a subpopulation of dorsolateral striatum (DLS)-projecting VTA dopamine (DA) neurons (VTA
DA
-DLS). While, VTA
DA
-DLS pathway stimulation decreases social interaction, VTA
DA
-Nucleus Accumbens stimulation promotes it. Altogether, these data support a model by which at least two largely anatomically distinct VTA sub-circuits oppositely control distinct aspects of social behaviour.
Solié, Contestabile et al. show that the superior colliculus to ventral tegmental area (VTA) pathway encodes orienting behavior toward conspecifics, and modulates VTA dopamine neurons projecting onto dorsolateral striatum perturbing social interaction.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 9/10
/ 9/74
/ Animals
/ Dopamine
/ Dopaminergic Neurons - physiology
/ Humanities and Social Sciences
/ Male
/ Mice
/ Neural Pathways - physiology
/ Neurons
/ Nucleus Accumbens - physiology
/ Orientation, Spatial - physiology
/ Prefrontal Cortex - physiology
/ Science
/ Superior Colliculi - pathology
