Asset Details
Do you wish to reserve the book?
Detection of impaired renal allograft function in paediatric and young adult patients using arterial spin labelling MRI (ASL-MRI)
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Detection of impaired renal allograft function in paediatric and young adult patients using arterial spin labelling MRI (ASL-MRI)
Do you wish to request the book?
Detection of impaired renal allograft function in paediatric and young adult patients using arterial spin labelling MRI (ASL-MRI)
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Detection of impaired renal allograft function in paediatric and young adult patients using arterial spin labelling MRI (ASL-MRI)
2022
Overview
The study aimed to discriminate renal allografts with impaired function by measuring cortical renal blood flow (cRBF) using magnetic resonance imaging arterial spin labelling (ASL-MRI) in paediatric and young adult patients. We included 18 subjects and performed ASL-MRI on 1.5 T MRI to calculate cRBF on parameter maps. cRBF was correlated to calculated glomerular filtration rate (GFR) and compared between patient groups with good (GFR ≥ 60 mL/min/1.73 m
2
) and impaired allograft function (GFR < 60 mL/min/1.73 m
2
). Mean cRBF in patients with good allograft function was significantly higher than in patients with impaired allograft function (219.89 ± 57.24 mL/min/100 g vs. 146.22 ± 41.84 mL/min/100 g,
p
< 0.008), showing a highly significant correlation with GFR in all subjects (r = 0.75,
p
< 0.0001). Also, the diffusion-weighted imaging (DWI-MRI) apparent diffusion coefficient (ADC) and Doppler measurements of peak-systolic and end-diastolic velocities and the resistive index (PS, ED, RI) were performed and both methods showed no significant difference between groups. ADC implied no correlation with GFR (r = 0.198,
p
= 0.464), while PS indicated moderate correlation to GFR (r = 0.48,
p
< 0.05), and PS and ED moderate correlation to cRBF (r = 0.58,
p
< 0.05, r = 0.56,
p
< 0.05, respectively). Cortical perfusion as non-invasively measured by ASL-MRI differs between patients with good and impaired allograft function and correlates significantly with its function.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 692/4022
/ 692/4025
/ Adult
/ Allografts - diagnostic imaging
/ Allografts - physiopathology
/ Child
/ Diastole
/ Diffusion Magnetic Resonance Imaging - methods
/ Female
/ Humanities and Social Sciences
/ Humans
/ Kidney Cortex - blood supply
/ Kidney Cortex - diagnostic imaging
/ Kidney Failure, Chronic - physiopathology
/ Kidney Failure, Chronic - surgery
/ Magnetic Resonance Imaging - methods
/ Male
/ Renal Circulation - physiology
/ Science
/ Systole
