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Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration
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Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration
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Journal Article
Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration
2018
Overview
While young muscle is capable of restoring the original architecture of damaged myofibers, aged muscle displays a markedly reduced regeneration. We show that expression of the “anti-aging” protein, α-Klotho, is up-regulated within young injured muscle as a result of transient
Klotho
promoter demethylation. However, epigenetic control of the
Klotho
promoter is lost with aging. Genetic inhibition of α-Klotho in vivo disrupted muscle progenitor cell (MPC) lineage progression and impaired myofiber regeneration, revealing a critical role for α-Klotho in the regenerative cascade. Genetic silencing of
Klotho
in young MPCs drove mitochondrial DNA (mtDNA) damage and decreased cellular bioenergetics. Conversely, supplementation with α-Klotho restored mtDNA integrity and bioenergetics of aged MPCs to youthful levels in vitro and enhanced functional regeneration of aged muscle in vivo in a temporally-dependent manner. These studies identify a role for α-Klotho in the regulation of MPC mitochondrial function and implicate α-Klotho declines as a driver of impaired muscle regeneration with age.
While young muscle faithfully regenerates damaged myofibers, aged muscle is impaired. Here the authors show the “anti-aging” protein α-Klotho is upregulated in young muscle after damage via promoter demethylation and this regulation is lost in aging, resulting in mitochondrial damage and an impaired healing response.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/100
/ 13/109
/ 13/31
/ 13/51
/ 14/1
/ 14/19
/ 14/63
/ 14/69
/ 147/143
/ 38/77
/ 38/88
/ 45/91
/ 49/15
/ 64/60
/ Aging
/ Animals
/ DNA
/ DNA, Mitochondrial - genetics
/ DNA, Mitochondrial - metabolism
/ Gene Expression Regulation, Developmental
/ Humanities and Social Sciences
/ Mice
/ Muscle, Skeletal - metabolism
/ Muscle, Skeletal - pathology
/ Muscles
/ Proteins
/ Receptors, Cell Surface - antagonists & inhibitors
/ Receptors, Cell Surface - genetics
/ Receptors, Cell Surface - metabolism
/ RNA, Small Interfering - genetics
/ RNA, Small Interfering - metabolism
/ Science
