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Interfacial-confined coordination to single-atom nanotherapeutics
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Journal Article
Interfacial-confined coordination to single-atom nanotherapeutics
2022
Overview
Pursuing and developing effective methodologies to construct highly active catalytic sites to maximize the atomic and energy efficiency by material engineering are attractive. Relative to the tremendous researches of carbon-based single atom systems, the construction of bio-applicable single atom materials is still in its infancy. Herein, we propose a facile and general interfacial-confined coordination strategy to construct high-quality single-atom nanotherapeutic agent with Fe single atoms being anchored on defective carbon dots confined in a biocompatible mesoporous silica nanoreactor. Furthermore, the efficient energy conversion capability of silica-based Fe single atoms system has been demonstrated on the basis of the exogenous physical photo irradiation and endogenous biochemical reactive oxygen species stimulus in the confined mesoporous network. More importantly, the highest photothermal conversion efficiency with the mechanism of increased electron density and narrow bandgap of this single atom structure in defective carbon was proposed by the theoretical DFT calculations. The present methodology provides a scientific paradigm to design and develop versatile single atom nanotherapeutics with adjustable metal components and tune the corresponding reactions for safe and efficient tumor therapeutic strategy.
Developing single atom systems with improved catalytic potential for bio-application has major therapeutic potential. Here, the authors report on the development of a metal single-atom on a carbon dot support confined within mesoporous silica for the development of therapeutic agents.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/31
/ 14/19
/ 14/34
/ 140/133
/ 140/146
/ 147/137
/ 147/143
/ 59/5
/ 64/60
/ Animals
/ Carbon
/ Carcinoma, Hepatocellular - metabolism
/ Carcinoma, Hepatocellular - pathology
/ Carcinoma, Hepatocellular - therapy
/ Energy conversion efficiency
/ Female
/ Ferrosoferric Oxide - chemistry
/ Humanities and Social Sciences
/ Humans
/ Light
/ Liver Neoplasms - metabolism
/ Metal Nanoparticles - administration & dosage
/ Metal Nanoparticles - chemistry
/ Metal Nanoparticles - ultrastructure
/ Mice
/ Photothermal Therapy - methods
/ Reactive Oxygen Species - agonists
/ Reactive Oxygen Species - metabolism
/ Science
/ Silica
/ Theranostic Nanomedicine - methods
/ Tumors
