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MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells
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MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells
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Journal Article
MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells
2020
Overview
MZB1 is an endoplasmic reticulum (ER)-resident protein that plays an important role in the humoral immune response by enhancing the interaction of the μ immunoglobulin (Ig) heavy chain with the chaperone GRP94 and by augmenting the secretion of IgM. Here, we show that MZB1 is also expressed in plasmacytoid dendritic cells (pDCs).
Mzb1
−/−
pDCs have a defect in the secretion of interferon (IFN) α upon Toll-like receptor (TLR) 9 stimulation and a reduced ability to enhance B cell differentiation towards plasma cells.
Mzb1
−/−
pDCs do not properly expand the ER upon TLR9 stimulation, which may be accounted for by an impaired activation of ATF6, a regulator of the unfolded protein response (UPR). Pharmacological inhibition of ATF6 cleavage in stimulated wild type pDCs mimics the diminished IFNα secretion by
Mzb1
−/−
pDCs. Thus, MZB1 enables pDCs to secrete high amounts of IFNα by mitigating ER stress via the ATF6-mediated UPR.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/80
/ Animals
/ Dendritic Cells - drug effects
/ Dendritic Cells - immunology
/ Dendritic Cells - metabolism
/ Humanities and Social Sciences
/ Immunoglobulin mu-Chains - immunology
/ Immunoglobulin mu-Chains - metabolism
/ Interferon-alpha - immunology
/ Interferon-alpha - metabolism
/ Mice
/ Molecular Chaperones - immunology
/ Molecular Chaperones - metabolism
/ Science
