Asset Details
Do you wish to reserve the book?
The development of synaptic transmission is time-locked to early social behaviors in rats
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The development of synaptic transmission is time-locked to early social behaviors in rats
Do you wish to request the book?
The development of synaptic transmission is time-locked to early social behaviors in rats
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The development of synaptic transmission is time-locked to early social behaviors in rats
2019
Overview
The development of functional synapses is a sequential process preserved across many brain areas. Here, we show that glutamatergic postsynaptic currents anticipated GABAergic currents in Layer II/III of the rat neocortex, in contrast to the pattern described for other brain areas. The frequencies of both glutamatergic and GABAergic currents increased abruptly at the beginning of the second postnatal week, supported by a serotonin upsurge. Integrative behaviors arose on postnatal day (P)9, while most motor and sensory behaviors, which are fundamental for pup survival, were already in place at approximately P7. A reduction in serotonin reuptake accelerated the development of functional synapses and integrative huddling behavior, while sparing motor and sensory function development. A decrease in synaptic transmission in Layer II/III induced by a chemogenetic approach only inhibited huddling. Thus, precise developmental sequences mediate early, socially directed behaviors for which neurotransmission and its modulation in supragranular cortical layers play key roles.
The development of functional synapses is a key milestone in neurodevelopment. Here, the authors show how serotonin signalling coordinates development of glutamatergic and GABAergic currents and triggers the emergence of integrative behavior (huddling) in rat pups.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/378
/ 64/86
/ 9/74
/ Animals
/ Behavior
/ Behavior, Animal - drug effects
/ Behavior, Animal - physiology
/ Brain
/ GABAergic Neurons - metabolism
/ Huddling
/ Humanities and Social Sciences
/ Motors
/ Neocortex - growth & development
/ Rats
/ Science
/ Serotonin Uptake Inhibitors - pharmacology
/ Somatosensory Cortex - drug effects
/ Somatosensory Cortex - physiology
/ Synapses
/ Synaptic Transmission - drug effects
