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Midbrain signaling of identity prediction errors depends on orbitofrontal cortex networks
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Midbrain signaling of identity prediction errors depends on orbitofrontal cortex networks
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Midbrain signaling of identity prediction errors depends on orbitofrontal cortex networks
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Journal Article
Midbrain signaling of identity prediction errors depends on orbitofrontal cortex networks
2024
Overview
Outcome-guided behavior requires knowledge about the identity of future rewards. Previous work across species has shown that the dopaminergic midbrain responds to violations in expected reward identity and that the lateral orbitofrontal cortex (OFC) represents reward identity expectations. Here we used network-targeted transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI) during a trans-reinforcer reversal learning task to test the hypothesis that outcome expectations in the lateral OFC contribute to the computation of identity prediction errors (iPE) in the midbrain. Network-targeted TMS aiming at lateral OFC reduced the global connectedness of the lateral OFC and impaired reward identity learning in the first block of trials. Critically, TMS disrupted neural representations of expected reward identity in the OFC and modulated iPE responses in the midbrain. These results support the idea that iPE signals in the dopaminergic midbrain are computed based on outcome expectations represented in the lateral OFC.
Behaviour requires knowledge of cues and outcomes. Here the authors use neuromodulation of lateral orbitofrontal cortex and neuroimaging of error-related midbrain activity to reveal the neurocomputational mechanisms underlying reward identity learning.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
