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Influence of false lumen status on systemic inflammatory response triggered by acute aortic dissection
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Influence of false lumen status on systemic inflammatory response triggered by acute aortic dissection
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Journal Article
Influence of false lumen status on systemic inflammatory response triggered by acute aortic dissection
2025
Overview
We investigated the influence of false lumen (FL) status on the systemic inflammatory response triggered by acute aortic dissection (AAD) using cytokine profiling. The study included 44 patients with AAD. Patients were divided between those with a thrombosed FL (Group T,
n
= 21) and those with a non-thrombosed FL (Group P,
n
= 23). On-admission serum concentrations of 29 cytokines were compared between unmatched and propensity-score matched (
n
= 10 pairs) FL groups and a control group (non-ruptured thoracic aortic aneurysm, Group C,
n
= 20). Unmatched analysis showed 12 cytokines differed between groups and fell into three categories: Category A (increased expression in both FL groups: IL-6, IL-10, IL-15, G-CSF); Category B (increased expression only in Group P: IL-1Ra, IL-1β, IL-8, IL-12p70, GM-CSF); and Category C (others: IP-10, VEGF-A, eotaxin). The increases in Category A and Category B cytokines in Group T were attenuated, but not significantly, compared to their increases in Group P. Propensity-score matching analysis revealed a similar expression pattern with respect to all four Category A cytokines, four Category B cytokines (IL-1β, IL-1Ra, IL-12p70, and GM-CSF), and two Category C cytokines (IP-10 and VEGF-A). A robust inflammatory response occurs in patients with AAD, but the response is attenuated when the FL is thrombosed.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 692/4019
/ Aged
/ Aortic Aneurysm, Thoracic - blood
/ Cytokine
/ Eotaxin
/ Female
/ Granulocyte colony-stimulating factor
/ Granulocyte-macrophage colony-stimulating factor
/ Humanities and Social Sciences
/ Humans
/ IL-1β
/ Interleukin 1 receptor antagonist
/ Male
/ Science
/ Systemic Inflammatory Response Syndrome - blood
/ Thorax
