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Galactooligosaccharides and Limosilactobacillus reuteri synergistically alleviate gut inflammation and barrier dysfunction by enriching Bacteroides acidifaciens for pentadecanoic acid biosynthesis
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Galactooligosaccharides and Limosilactobacillus reuteri synergistically alleviate gut inflammation and barrier dysfunction by enriching Bacteroides acidifaciens for pentadecanoic acid biosynthesis
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Journal Article
Galactooligosaccharides and Limosilactobacillus reuteri synergistically alleviate gut inflammation and barrier dysfunction by enriching Bacteroides acidifaciens for pentadecanoic acid biosynthesis
2024
Overview
Ulcerative colitis (UC) is a debilitating inflammatory bowel disease characterized by intestinal inflammation, barrier dysfunction, and dysbiosis, with limited treatment options available. This study systematically investigates the therapeutic potential of a synbiotic composed of galactooligosaccharides (GOS) and
Limosilactobacillus reuteri
in a murine model of colitis, revealing that GOS and
L. reuteri
synergistically protect against intestinal inflammation and barrier dysfunction by promoting the synthesis of pentadecanoic acid, an odd-chain fatty acid, from
Bacteroides acidifaciens
. Notably, the synbiotic,
B. acidifaciens
, and pentadecanoic acid are each capable of suppressing intestinal inflammation and enhancing tight junction by inhibiting NF-κB activation. Furthermore, similar reduction in
B. acidifaciens
and pentadecanoic acid levels are also observed in the feces from both human UC patients and lipopolysaccharide-induced intestinal inflammation in pigs. Our findings elucidate the protective mechanism of the synbiotic and highlight its therapeutic potential, along with
B. acidifaciens
and pentadecanoic acid, for UC and other intestinal inflammatory disorders.
Here, Yujun Wu and colleagues report that a synbiotic composed of galactooligosaccharides and
Limosilactobacillus reuteri
alleviates gut inflammation in animals by enriching pentadecanoic acid synthesis from
Bacteroides acidifaciens
, showing potential for treating ulcerative colitis.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/21
/ 38
/ 38/23
/ 38/77
/ 38/91
/ 64/60
/ Animals
/ Colitis, Ulcerative - chemically induced
/ Colitis, Ulcerative - drug therapy
/ Colitis, Ulcerative - immunology
/ Colitis, Ulcerative - metabolism
/ Colitis, Ulcerative - microbiology
/ Colitis, Ulcerative - pathology
/ Gastrointestinal Microbiome - drug effects
/ Humanities and Social Sciences
/ Humans
/ Limosilactobacillus reuteri - metabolism
/ Male
/ Mice
/ Oligosaccharides - administration & dosage
/ Oligosaccharides - pharmacology
/ Science
/ Swine
/ Synbiotics - administration & dosage
/ Tight Junctions - drug effects
