Journal Article

Reservoir displacement by an invasive rodent reduces Lassa virus zoonotic spillover risk

Fichet-Calvet, Elisabeth, Lungay, Victor, Ghersi, Bruno M., Kanu, Marilyn C., Vandi, Mohamed A., Kanu, Osman T., Eskew, Evan A., Bangura, James, Bah, Mohamed A., Lavalie, Edwin G., Basinski, Andrew J., Bird, Brian H., Amara, Emmanuel, Robert, Willie, Nuismer, Scott L.

2024

Overview

The black rat ( Rattus rattus ) is a globally invasive species that has been widely introduced across Africa. Within its invasive range in West Africa, R. rattus may compete with the native rodent Mastomys natalensis , the primary reservoir host of Lassa virus, a zoonotic pathogen that kills thousands annually. Here, we use rodent trapping data from Sierra Leone and Guinea to show that R. rattus presence reduces M. natalensis density within the human dwellings where Lassa virus exposure is most likely to occur. Further, we integrate infection data from M. natalensis to demonstrate that Lassa virus zoonotic spillover risk is lower at sites with R. rattus . While non-native species can have numerous negative effects on ecosystems, our results suggest that R. rattus invasion has the indirect benefit of decreasing zoonotic spillover of an endemic pathogen, with important implications for invasive species control across West Africa. Mastomys natalensis is a rodent species native to West Africa that is the primary reservoir host for Lassa virus. Here, the authors investigate whether the invasive rodent Rattus rattus decreases M. natalensis density and could therefore indirectly decrease zoonotic transmission of Lassa virus to humans.

• Publisher: Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
• Subject: 631/158/2178 / 631/158/853 / 692/699/255/2514 / 692/700/478/174 / Animals / Disease Reservoirs - virology / Ecosystem / Guinea - epidemiology / Humanities and Social Sciences / Humans / Indigenous species / Introduced Species / Invasive species / Lassa Fever - epidemiology / Lassa Fever - transmission / Lassa Fever - veterinary / Lassa Fever - virology / Lassa virus - pathogenicity / Lassa virus - physiology / Mastomys natalensis / multidisciplinary / Murinae - virology / Nonnative species / Pathogens / Population density / Rats / Rattus rattus / Rodent Diseases - epidemiology / Rodent Diseases - transmission / Rodent Diseases - virology / Rodents / Science / Science (multidisciplinary) / Sierra Leone - epidemiology / Viruses / Zoonoses / Zoonoses - epidemiology / Zoonoses - transmission / Zoonoses - virology