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Functional large-conductance calcium and voltage-gated potassium channels in extracellular vesicles act as gatekeepers of structural and functional integrity
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Functional large-conductance calcium and voltage-gated potassium channels in extracellular vesicles act as gatekeepers of structural and functional integrity
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Journal Article
Functional large-conductance calcium and voltage-gated potassium channels in extracellular vesicles act as gatekeepers of structural and functional integrity
2025
Overview
Extracellular vesicles (EVs) are associated with intercellular communications, immune responses, viral pathogenicity, cardiovascular diseases, neurological disorders, and cancer progression. EVs deliver proteins, metabolites, and nucleic acids into recipient cells to effectively alter their physiological and biological response. During their transportation from the donor to the recipient cell EVs face differential ionic concentrations, which can be detrimental to their integrity and impact their cargo content. EVs are known to possess ion channels and transporters in their membrane but neither the function nor the role of these channels in EVs is known. In this study, we discover a functional calcium-activated large-conductance potassium channel (BK
Ca
) in the membrane of EVs. Furthermore, we establish that BK
Ca
is essential for the structural and functional integrity of EVs. Together, these findings establish the critical role of ion channels such as BK
Ca
in functioning as gatekeepers and maintaining EV-mediated signaling.
Extracellular vesicles secreted by cells play a crucial role in cellular communication. Here, the authors identify a functional BK channel in extracellular vesicle membranes and establish its role in preserving vesicle integrity, K+ homeostasis, and physiological function.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/61
/ 64/60
/ 9/97
/ Animals
/ Calcium
/ Calcium channels (voltage-gated)
/ Extracellular Vesicles - metabolism
/ Humanities and Social Sciences
/ Humans
/ Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - genetics
/ Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - metabolism
/ Large-Conductance Calcium-Activated Potassium Channels - metabolism
/ Mice
/ Potassium channels (voltage-gated)
/ Potassium Channels, Voltage-Gated - genetics
/ Potassium Channels, Voltage-Gated - metabolism
/ Science
/ Structure-function relationships
/ Vesicles
