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Lactiplantibacillus plantarum 22 A-3 ameliorates leaky gut in mice through its anti-inflammatory effects
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Lactiplantibacillus plantarum 22 A-3 ameliorates leaky gut in mice through its anti-inflammatory effects
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Journal Article
Lactiplantibacillus plantarum 22 A-3 ameliorates leaky gut in mice through its anti-inflammatory effects
2025
Overview
There are limited studies on the improvement of leaky gut with minor inflammation associated with various diseases. To explore the therapeutic potential of
Lactiplantibacillus plantarum 22 A-3
, a member of the
Lactobacillus
species, in addressing a leaky gut.
Lactiplantibacillus plantarum 22 A-3
was administered to a leaky gut mice model with low dextran sulfate sodium concentrations. The
Lactiplantibacillus plantarum 22 A-3
-treated group exhibited amelioration of increased intestinal permeability, as indicated by lower blood fluorescein isothiocyanate-dextran levels compared with that of the control group. Furthermore, the messenger RNA expression of interleukin-10, an anti-inflammatory cytokine, was upregulated in the small intestine of
Lactiplantibacillus plantarum 22 A-3
-treated mice. Moreover, forkhead box P3 was upregulated in the small intestine and colon following
Lactiplantibacillus plantarum 22 A-3
administration. Flow cytometry showed that forkhead box P3-positive regulatory T cells tended to increase in the small intestine and colon; however, this was not significant. Messenger RNA levels for the pro-inflammatory cytokines, interleukin-1 beta, and tumor necrosis factor-alpha showed no significant changes in the small intestine; however, their expressions significantly decreased in the colon. Blood fluorescein isothiocyanate-dextran levels showed that intestinal permeability also decreased in
Lactiplantibacillus plantarum 22 A-3
-dead bacteria. The bacterial component of
Lactiplantibacillus plantarum 22 A-3
ameliorates increased intestinal permeability through its anti-inflammatory effect in the intestinal tract and may be a novel treatment for leaky gut.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Animals
/ Anti-Inflammatory Agents - pharmacology
/ Blood
/ Colon
/ Dextran
/ Forkhead Transcription Factors - metabolism
/ Humanities and Social Sciences
/ Intestinal Mucosa - metabolism
/ Intestine, Small - metabolism
/ Intestine, Small - microbiology
/ Lactiplantibacillus plantarum
/ Lactiplantibacillus plantarum 22A-3
/ Male
/ Mice
/ Science
