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Valence-engineered catalysis-selectivity regulation of molybdenum oxide nanozyme for acute kidney injury therapy and post-cure assessment
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Valence-engineered catalysis-selectivity regulation of molybdenum oxide nanozyme for acute kidney injury therapy and post-cure assessment
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Journal Article
Valence-engineered catalysis-selectivity regulation of molybdenum oxide nanozyme for acute kidney injury therapy and post-cure assessment
2024
Overview
The optimization of the enzyme-like catalytic selectivity of nanozymes for specific reactive oxygen species (ROS)-related applications is significant, and meanwhile the real-time monitoring of ROS is really crucial for tracking the therapeutic process. Herein, we present a mild oxidation valence-engineering strategy to modulate the valence states of Mo in Pluronic F127-coated MoO
3-x
nanozymes (denoted as MF-x, x: oxidation time) in a controlled manner aiming to improve their specificity of H
2
O
2
-associated catalytic reactions for specific therapy and monitoring of ROS-related diseases. Experimentally, MF-0 (Mo average valence 4.64) and MF-10 (Mo average valence 5.68) exhibit exclusively optimal catalase (CAT)- or peroxidase (POD)-like activity, respectively. Density functional theory (DFT) calculations verify the most favorable reaction path for both MF-0- and MF-10-catalyzed reaction processes based on free energy diagram and electronic structure analysis, disclosing the mechanism of the H
2
O
2
activation pathway on the Mo-based nanozymes. Furthermore, MF-0 poses a strong potential in acute kidney injury (AKI) treatment, achieving excellent therapeutic outcomes in vitro and in vivo. Notably, the ROS-responsive photoacoustic imaging (PAI) signal of MF-0 during treatment guarantees real-time monitoring of the therapeutic effect and post-cure assessment in vivo, providing a highly desirable non-invasive diagnostic approach for ROS-related diseases.
Nanozymes can mimic the activity of natural enzymes but are limited by poor reaction selectivity due to the lack of enzyme-like molecular recognition units as in natural enzymes. Here, the authors present a mild oxidation valence-engineering strategy to modulate the valence states of Mo in Pluronic F127-coated MoO
3-x
nanozymes and show they can exhibit exclusive catalase- or peroxidase-like activities.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/63
/ 140/146
/ 147/143
/ 64/60
/ Acute Kidney Injury - drug therapy
/ Acute Kidney Injury - metabolism
/ Animals
/ Catalase
/ Enzymes
/ Humanities and Social Sciences
/ Humans
/ Hydrogen Peroxide - chemistry
/ Hydrogen Peroxide - metabolism
/ Kidneys
/ Male
/ Mice
/ Reactive Oxygen Species - metabolism
/ Science
/ Valence
