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Unveiling fungal strategies: Mycoremediation in multi-metal pesticide environment using proteomics
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Unveiling fungal strategies: Mycoremediation in multi-metal pesticide environment using proteomics
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Journal Article
Unveiling fungal strategies: Mycoremediation in multi-metal pesticide environment using proteomics
2024
Overview
Micropollutants, such as heavy metals and pesticides, inhibit microbial growth, threatening ecosystems. Yet, the mechanism behind mycoremediation of the pesticide lindane and multiple metals (Cd, Total Cr, Cu, Ni, Pb, Zn) remains poorly understood. In our study, we investigated cellular responses in
Aspergillus fumigatus
PD-18 using LC-MS/MS, identifying 2190 proteins, 1147 of which were consistently present under both stress conditions. Specifically, Cu-Zn superoxide dismutase and heat shock proteins were up-regulated to counter oxidative stress and protein misfolding. Proteins involved in intracellular trafficking, secretion, and vesicular transport; RNA processing and modification showed enhanced abundance and regulating stress response pathways. Additionally, haloalkane dehalogenase and homogentisate 1,2-dioxygenase played pivotal roles in lindane mineralization. Bioinformatics analysis highlighted enriched pathways such as Glyoxylate and dicarboxylate metabolism and Purine metabolism, that are crucial for combating adverse environments. We identified the hub protein 26 S proteasome regulatory subunit complex as potential biomarker and remedial targets for mycoremediation of wastewater, suggesting practical applications for environmental remediation.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/553
/ 704/172
/ Aspergillus fumigatus - drug effects
/ Aspergillus fumigatus - genetics
/ Aspergillus fumigatus - metabolism
/ Biodegradation, Environmental
/ Cadmium
/ Chromium
/ Copper
/ Fungal Proteins - metabolism
/ Hexachlorocyclohexane - metabolism
/ Homogentisate 1,2-dioxygenase
/ Humanities and Social Sciences
/ Lindane
/ Proteins
/ Science
