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Antihypertensive effect of sinapine extracted from rapeseed meal in 2K1C hypertensive rats
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Antihypertensive effect of sinapine extracted from rapeseed meal in 2K1C hypertensive rats
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Journal Article
Antihypertensive effect of sinapine extracted from rapeseed meal in 2K1C hypertensive rats
2025
Overview
To extract
sinapine
from rapeseed meal and investigate its antihypertensive function and mechanism. Blood pressure was measured before and after
sinapine
administration to evaluate
sinapine’s
immediate antihypertensive function. Twokidney, oneclip (2K1C) hypertensive rats were given
sinapine
for four weeks, with weekly blood pressure monitoring. The renin angiotensin aldosterone system (RAAS), including the levels of renin, angiotensin I (Ang I), angiotensin II (Ang II), aldosterone (ALD), angiotensin-converting enzyme (ACE) and other molecules related to blood pressure, such as NO, prostacyclin (PGI
2
), endothelin-1 (ET1), and thromboxane A
2
(TXA
2
), were measured in rat blood. The impact of
sinapine
on vascular endothelial cell (A10) calcium and potassium channels was assessed using the patch-clamp technique. One-time or long-term administration of
sinapine
significantly reduced the rats’ systolic blood pressure (SBP), diastolic pressure (DBP), and mean blood pressure (MBP).
Sinapine
also decreased the levels of Ang II and ALD. Furthermore,
sinapine
effectively inhibited ACE activation, increased NO levels, and blocked L-type calcium channels.
Sinapine
has an antihypertensive function and achieves this process through multiple targets.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Animals
/ Antihypertensive Agents - pharmacology
/ Antihypertensive Agents - therapeutic use
/ Blood Pressure - drug effects
/ Choline - analogs & derivatives
/ Enzymes
/ Humanities and Social Sciences
/ Male
/ Peptidyl-Dipeptidase A - metabolism
/ RAAS
/ Rats
/ Renin
/ Renin-Angiotensin System - drug effects
/ Science
/ Sinapine
