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On the utility of cerebrospinal fluid biomarkers in canine neurological disorders
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On the utility of cerebrospinal fluid biomarkers in canine neurological disorders
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Journal Article
On the utility of cerebrospinal fluid biomarkers in canine neurological disorders
2024
Overview
The cerebral biomarkers, neurofilament light chain (NfL), amyloid-β, tau, and neuron specific enolase (NSE) reflect a wide spectrum of neurological damage in the brain and spinal cord. With this study, we aimed to assess whether these biomarkers hold any potential diagnostic value for the three most common canine neurological diseases. Canines suffering from meningoencephalitis of unknown origin (MUO), brain tumors, and selected non-infectious myelopathies were included. For each diagnosis, we analyzed these biomarkers in the cerebrospinal fluid collected via cranial puncture from the cisterna magna. Elevated levels of CSF tau, NfL, and NSE were observed in MUO, with all three biomarkers being intercorrelated. Tau and NSE were increased while amyloid-β was decreased in dogs suffering from tumors. In contrast, no biomarker changes were observed in dogs with myelopathies. Covariates such as age, sex, or castration had minimal impact. CSF biomarkers may reflect molecular changes related to MUO and tumors, but not to non-infectious myelopathies. The combination of NfL, tau, and NSE may represent useful biomarkers for MUO as they reflect the same pathology and are not influenced by age.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/67
/ Amyloid beta-Peptides - cerebrospinal fluid
/ Animals
/ Biomarkers - cerebrospinal fluid
/ Brain Neoplasms - cerebrospinal fluid
/ Brain Neoplasms - veterinary
/ Dog Diseases - cerebrospinal fluid
/ Dogs
/ Female
/ Humanities and Social Sciences
/ Male
/ Meningoencephalitis - cerebrospinal fluid
/ Meningoencephalitis - diagnosis
/ Meningoencephalitis - veterinary
/ Nervous System Diseases - cerebrospinal fluid
/ Nervous System Diseases - diagnosis
/ Nervous System Diseases - veterinary
/ Neurofilament Proteins - cerebrospinal fluid
/ Phosphopyruvate Hydratase - cerebrospinal fluid
/ Science
/ tau Proteins - cerebrospinal fluid
/ Tumors
