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Exploiting lung adaptation and phage steering to clear pan-resistant Pseudomonas aeruginosa infections in vivo
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Exploiting lung adaptation and phage steering to clear pan-resistant Pseudomonas aeruginosa infections in vivo
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Journal Article
Exploiting lung adaptation and phage steering to clear pan-resistant Pseudomonas aeruginosa infections in vivo
2024
Overview
Pseudomonas aeruginosa
is a major nosocomial pathogen that causes severe disease including sepsis. Carbapenem-resistant
P. aeruginosa
is recognised by the World Health Organisation as a priority 1 pathogen, with urgent need for new therapeutics. As such, there is renewed interest in using bacteriophages as a therapeutic. However, the dynamics of treating pan-resistant
P. aeruginosa
with phage in vivo are poorly understood. Using a pan-resistant
P. aeruginosa
in vivo infection model, phage therapy displays strong therapeutic potential, clearing infection from the blood, kidneys, and spleen. Remaining bacteria in the lungs and liver displays phage resistance due to limiting phage adsorption. Yet, resistance to phage results in re-sensitisation to a wide range of antibiotics. In this work, we use phage steering in vivo, pre-exposing a pan resistant
P. aeruginosa
infection with a phage cocktail to re-sensitise bacteria to antibiotics, clearing the infection from all organs.
In this work, authors utilise a pan-resistant
Pseudomonas aeruginosa
in vivo infection model to demonstrate antibiotic re-sensitisation with bacteriophage therapy.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
