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Expression of ANK3 moderates the association between childhood trauma and affective traits in severe mental disorders
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Expression of ANK3 moderates the association between childhood trauma and affective traits in severe mental disorders
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Journal Article
Expression of ANK3 moderates the association between childhood trauma and affective traits in severe mental disorders
2023
Overview
Exposure to early life trauma increases the risk of psychopathology later in life. Here we investigated if
ANK3
mRNA levels influence the relationship between childhood trauma experiences and clinical characteristics in mental disorders. A sample of 174 patients with bipolar disorder and 291 patients with schizophrenia spectrum disorder were included. Patients were diagnosed using the Structured Clinical Interview for DSM-IV, and childhood trauma was assessed using the childhood trauma questionnaire. Age at illness onset and number of psychotic and affective episodes were assessed from interview and medical records. Current depressive symptoms were measured using the calgary depression scale for schizophrenia and the inventory for depressive symptomatology.
ANK3
expression was analyzed in whole blood using the Illumina HumanHT-12 v4 Expression BeadChip. Analyses were carried out with the
Process
adjusted for confounders. Within the total sample, patients with both high
ANK3
expression and with the most severe childhood sexual abuse had more manic/hypomanic episodes and an earlier age at onset of the first episode.
ANK3
mRNA levels also moderated the relationship between emotional neglect and manic/hypomanic episodes. Our results suggest that
ANK3
expression levels moderate the association between specific types of childhood trauma and affective traits in mental disorders.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Adverse Childhood Experiences
/ Children
/ Humanities and Social Sciences
/ Humans
/ Mania
/ mRNA
/ Patients
/ Science
/ Trauma
