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PTEN Mutations as a Cause of Constitutive Insulin Sensitivity and Obesity

by Karpe, Fredrik , Walker, Lisa , Van de Bunt, Martijn , Linden, Helen , Lachlan, Katherine L , Levy, Jonathan C , Gloyn, Anna L , Barber, Thomas M , Pal, Aparna , Cooper, Nicola S , Zhang, Qifeng , Rudge, Simon A , Wakelam, Michael J.O

in 1-Phosphatidylinositol 3-kinase / Absorptiometry / Adiponectin - blood / Adipose Tissue / Adult / Aged / AKT protein / Anthropomorphism / Beta cells / Biological and medical sciences / Biomedical research / Biopsy / Body composition / Body mass / Body Mass Index / Cancer / Cell growth / Diabetes / Diabetes mellitus / Diabetes mellitus (non-insulin dependent) / Diabetes Mellitus, Type 2 - genetics / Epidemiology / Female / General aspects / Glucose / Glucose Tolerance Test / Haploinsufficiency / Humans / Insulin / Insulin resistance / Insulin Resistance - genetics / Laboratories / Leptin - blood / Male / Medical sciences / Metabolic diseases / Metabolism / Middle Aged / Mutation / Neoplasms - complications / Neoplasms - genetics / Obesity / Obesity - complications / Obesity - genetics / Phosphatase / Phosphorylation / Population studies / PTEN Phosphohydrolase - genetics / PTEN protein / Skinfold thickness / Tensin / Thyroid gland

2012

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2012

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2012

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Journal Article

PTEN Mutations as a Cause of Constitutive Insulin Sensitivity and Obesity

Karpe, Fredrik,

Walker, Lisa,

Van de Bunt, Martijn,

Linden, Helen,

Lachlan, Katherine L,

Levy, Jonathan C,

Gloyn, Anna L,

Barber, Thomas M,

Pal, Aparna,

Cooper, Nicola S,

Zhang, Qifeng,

Rudge, Simon A,

Wakelam, Michael J.O

2012

Overview

Evidence suggests that protection against cancer confers a risk of type 2 diabetes and vice versa. This study shows that persons susceptible to cancer owing to a constitutive mutation in the tumor-suppressor gene PTEN also have heightened sensitivity to insulin and are obese. Epidemiologic evidence for a link among type 2 diabetes, obesity, and cancer has increased interest in the idea that some antidiabetes therapies may increase the risk of susceptibility to cancer, whereas others appear to offer protection. 1 Such a link is also supported by the discovery of several susceptibility loci for type 2 diabetes and their unexpected proximity to genes implicated in cell-cycle regulation. 2 The discovery of common genetic variants that influence both the risk of cancer and the risk of type 2 diabetes, in opposite directions, suggests that the two conditions may result from defects in the same pathway. 3 – . . .

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Publisher

Massachusetts Medical Society

Subject

1-Phosphatidylinositol 3-kinase

/ Absorptiometry

/ Adiponectin - blood

/ Adipose Tissue

/ Adult

/ Aged

/ AKT protein