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Designing a multi-epitope influenza vaccine: an immunoinformatics approach
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Designing a multi-epitope influenza vaccine: an immunoinformatics approach
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Journal Article
Designing a multi-epitope influenza vaccine: an immunoinformatics approach
2024
Overview
Influenza continues to be one of the top public health problems since it creates annual epidemics and can start a worldwide pandemic. The virus’s rapid evolution allows the virus to evade the host defense, and then seasonal vaccines need to be reformulated nearly annually. However, it takes almost half a year for the influenza vaccine to become accessible. This delay is especially concerning in the event of a pandemic breakout. By producing the vaccine through reverse vaccinology and phage display vaccines, this time can be reduced. In this study, epitopes of B lymphocytes, cytotoxic T lymphocytes, and helper T lymphocytes of HA, NA, NP, and M2 proteins from two strains of Influenza A were anticipated. We found two proper epitopes (ASFIYNGRL and LHLILWITDRLFFKC) in Influenza virus proteins for CTL and HTL cells, respectively. Optimal epitopes and linkers
in silico
were cloned into the N-terminal end of M13 protein III (pIII) to create a multi-epitope-pIII construct, i.e., phage display vaccine. Also, prediction of tertiary structure, molecular docking, molecular dynamics simulation, and immune simulation were performed and showed that the designed multi-epitope vaccine can bind to the receptors and stimulate the immune system response.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Computational Biology - methods
/ Epitopes
/ Epitopes, B-Lymphocyte - chemistry
/ Epitopes, B-Lymphocyte - immunology
/ Epitopes, T-Lymphocyte - chemistry
/ Epitopes, T-Lymphocyte - immunology
/ Humanities and Social Sciences
/ Humans
/ Influenza A virus - immunology
/ Influenza Vaccines - immunology
/ Influenza, Human - immunology
/ Influenza, Human - prevention & control
/ Molecular Docking Simulation
/ Molecular Dynamics Simulation
/ Science
/ T-Lymphocytes, Cytotoxic - immunology
/ Vaccines
/ Viruses
