Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA

by James, C. David , Reed, Rachel , Visnyei, Koppany , Yang, Huijun , Gomez, German , Paucar, Andres , Nelson, Stanley F. , Cavenee, Webster K. , Mischel, Paul S. , Masui, Kenta , Kornblum, Harley I. , Hwang, Kiwook , Wykosky, Jill , Rao, P. Nagesh , Furnari, Frank B. , Estin, Ascia , Nathanson, David A. , Wang, Jun , Heath, James R. , Koga, Tomoyuki , Ohashi, Minori , Gini, Beatrice , Mottahedeh, Jack , Zhu, Shaojun , Cloughesy, Timothy F.

in Animals / Antineoplastic Agents - therapeutic use / Cancer / Cancer therapies / Cell growth / Central Nervous System Neoplasms - drug therapy / Central Nervous System Neoplasms - genetics / Chromosomes / Deoxyribonucleic acid / DNA / DNA - genetics / Drug Rehabilitation / Drug resistance / Drug Resistance, Neoplasm - genetics / Drug Therapy / drugs / Epidermal growth factor / epidermal growth factor receptors / ErbB Receptors - antagonists & inhibitors / ErbB Receptors - genetics / Erlotinib Hydrochloride / Fluorescence in situ hybridization / genes / Glioblastoma - drug therapy / Glioblastoma - genetics / Heterogeneity / Humans / Medical schools / Metaphase / Mice / Molecular Targeted Therapy / Mutagenesis / Mutants / Mutation / neoplasm cells / Neoplasm Transplantation / neoplasms / Neurons / Oncogenes / Patients / Pharmaceutical sciences / Protein Kinase Inhibitors - therapeutic use / Quinazolines - therapeutic use / Single-Cell Analysis / Studies / Tumor Cells, Cultured / Tumors / Withholding Treatment

2014

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA

2014

Confirm

Do you wish to request the book?

Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA

2014

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA

James, C. David,

Reed, Rachel,

Visnyei, Koppany,

Yang, Huijun,

Gomez, German,

Paucar, Andres,

Nelson, Stanley F.,

Cavenee, Webster K.,

Mischel, Paul S.,

Masui, Kenta,

Kornblum, Harley I.,

Hwang, Kiwook,

Wykosky, Jill,

Rao, P. Nagesh,

Furnari, Frank B.,

Estin, Ascia,

Nathanson, David A.,

Wang, Jun,

Heath, James R.,

Koga, Tomoyuki,

Ohashi, Minori,

Gini, Beatrice,

Mottahedeh, Jack,

Zhu, Shaojun,

Cloughesy, Timothy F.

2014

Overview

Intratumoral heterogeneity contributes to cancer drug resistance, but the underlying mechanisms are not understood. Single-cell analyses of patient-derived models and clinical samples from glioblastoma patients treated with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) demonstrate that tumor cells reversibly up-regulate or suppress mutant EGFR expression, conferring distinct cellular phenotypes to reach an optimal equilibrium for growth. Resistance to EGFR TKIs is shown to occur by elimination of mutant EGFR from extrachromosomal DNA. After drug withdrawal, reemergence of donai EGFR mutations on extrachromosomal DNA follows. These results indicate a highly specific, dynamic, and adaptive route by which cancers can evade therapies that target oncogenes maintained on extrachromosomal DNA.

Share this book

Add to My Shelf

Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

Animals

/ Antineoplastic Agents - therapeutic use

/ Cancer

/ Cancer therapies

/ Cell growth

/ Central Nervous System Neoplasms - drug therapy

/ Central Nervous System Neoplasms - genetics