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A Systematic Review of Commercial Hybrid Closed-Loop Automated Insulin Delivery Systems
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A Systematic Review of Commercial Hybrid Closed-Loop Automated Insulin Delivery Systems
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A Systematic Review of Commercial Hybrid Closed-Loop Automated Insulin Delivery Systems
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Journal Article
A Systematic Review of Commercial Hybrid Closed-Loop Automated Insulin Delivery Systems
2023
Overview
Introduction
Several different forms of automated insulin delivery systems (AID systems) have recently been developed and are now licensed for type 1 diabetes (T1D). We undertook a systematic review of reported trials and real-world studies for commercial hybrid closed-loop (HCL) systems.
Methods
Pivotal, phase III and real-world studies using commercial HCL systems that are currently approved for use in type 1 diabetes were reviewed with a devised protocol using the Medline database.
Results
Fifty-nine studies were included in the systematic review (19 for 670G; 8 for 780G; 11 for Control-IQ; 14 for CamAPS FX; 4 for Diabeloop; and 3 for Omnipod 5). Twenty were real-world studies, and 39 were trials or sub-analyses. Twenty-three studies, including 17 additional studies, related to psychosocial outcomes and were analysed separately.
Conclusions
These studies highlighted that HCL systems improve time In range (TIR) and arouse minimal concerns around severe hypoglycaemia. HCL systems are an effective and safe option for improving diabetes care. Real-world comparisons between systems and their effects on psychological outcomes require further study.
