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Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma
by
Petrylak, Daniel P
, Castellano, Daniel
, Sonpavde, Guru P
, Rosenberg, Jonathan E
, Lee, Jae-Lyun
, Vulsteke, Christof
, Campbell, Mary
, Loriot, Yohann
, Wu, Chunzhang
, Durán, Ignacio
, Matsangou, Maria
, Matsubara, Nobuaki
, Powles, Thomas
in
Adult
/ Adverse events
/ Aged
/ Aged, 80 and over
/ Antibodies, Monoclonal - adverse effects
/ Antibodies, Monoclonal - therapeutic use
/ Antineoplastic Agents, Immunological - adverse effects
/ Antineoplastic Agents, Immunological - therapeutic use
/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use
/ Apoptosis
/ Bladder cancer
/ Body weight
/ Cell Adhesion Molecules - antagonists & inhibitors
/ Cell death
/ Chemotherapy
/ Confidence intervals
/ Disease control
/ Drug dosages
/ Drug Resistance, Neoplasm
/ Female
/ Humans
/ Intention to Treat Analysis
/ Male
/ Metastases
/ Metastasis
/ Middle Aged
/ Monoclonal antibodies
/ Paclitaxel
/ Patients
/ PD-1 protein
/ PD-L1 protein
/ Platinum
/ Programmed Cell Death 1 Ligand 2 Protein - antagonists & inhibitors
/ Programmed Cell Death 1 Receptor - antagonists & inhibitors
/ Progression-Free Survival
/ Survival Analysis
/ Targeted cancer therapy
/ Urologic Neoplasms - drug therapy
/ Urologic Neoplasms - mortality
/ Urologic Neoplasms - pathology
/ Urothelial carcinoma
/ Urothelium - pathology
2021
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Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma
by
Petrylak, Daniel P
, Castellano, Daniel
, Sonpavde, Guru P
, Rosenberg, Jonathan E
, Lee, Jae-Lyun
, Vulsteke, Christof
, Campbell, Mary
, Loriot, Yohann
, Wu, Chunzhang
, Durán, Ignacio
, Matsangou, Maria
, Matsubara, Nobuaki
, Powles, Thomas
in
Adult
/ Adverse events
/ Aged
/ Aged, 80 and over
/ Antibodies, Monoclonal - adverse effects
/ Antibodies, Monoclonal - therapeutic use
/ Antineoplastic Agents, Immunological - adverse effects
/ Antineoplastic Agents, Immunological - therapeutic use
/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use
/ Apoptosis
/ Bladder cancer
/ Body weight
/ Cell Adhesion Molecules - antagonists & inhibitors
/ Cell death
/ Chemotherapy
/ Confidence intervals
/ Disease control
/ Drug dosages
/ Drug Resistance, Neoplasm
/ Female
/ Humans
/ Intention to Treat Analysis
/ Male
/ Metastases
/ Metastasis
/ Middle Aged
/ Monoclonal antibodies
/ Paclitaxel
/ Patients
/ PD-1 protein
/ PD-L1 protein
/ Platinum
/ Programmed Cell Death 1 Ligand 2 Protein - antagonists & inhibitors
/ Programmed Cell Death 1 Receptor - antagonists & inhibitors
/ Progression-Free Survival
/ Survival Analysis
/ Targeted cancer therapy
/ Urologic Neoplasms - drug therapy
/ Urologic Neoplasms - mortality
/ Urologic Neoplasms - pathology
/ Urothelial carcinoma
/ Urothelium - pathology
2021
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Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma
by
Petrylak, Daniel P
, Castellano, Daniel
, Sonpavde, Guru P
, Rosenberg, Jonathan E
, Lee, Jae-Lyun
, Vulsteke, Christof
, Campbell, Mary
, Loriot, Yohann
, Wu, Chunzhang
, Durán, Ignacio
, Matsangou, Maria
, Matsubara, Nobuaki
, Powles, Thomas
in
Adult
/ Adverse events
/ Aged
/ Aged, 80 and over
/ Antibodies, Monoclonal - adverse effects
/ Antibodies, Monoclonal - therapeutic use
/ Antineoplastic Agents, Immunological - adverse effects
/ Antineoplastic Agents, Immunological - therapeutic use
/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use
/ Apoptosis
/ Bladder cancer
/ Body weight
/ Cell Adhesion Molecules - antagonists & inhibitors
/ Cell death
/ Chemotherapy
/ Confidence intervals
/ Disease control
/ Drug dosages
/ Drug Resistance, Neoplasm
/ Female
/ Humans
/ Intention to Treat Analysis
/ Male
/ Metastases
/ Metastasis
/ Middle Aged
/ Monoclonal antibodies
/ Paclitaxel
/ Patients
/ PD-1 protein
/ PD-L1 protein
/ Platinum
/ Programmed Cell Death 1 Ligand 2 Protein - antagonists & inhibitors
/ Programmed Cell Death 1 Receptor - antagonists & inhibitors
/ Progression-Free Survival
/ Survival Analysis
/ Targeted cancer therapy
/ Urologic Neoplasms - drug therapy
/ Urologic Neoplasms - mortality
/ Urologic Neoplasms - pathology
/ Urothelial carcinoma
/ Urothelium - pathology
2021
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Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma
Journal Article
Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma
2021
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Overview
Patients who had had a relapse after receiving platinum-containing chemotherapy and a PD-1 or PD-L1 immune checkpoint inhibitor were assigned to receive enfortumab vedotin or one of three chemotherapy agents chosen by their doctor. Enfortumab vedotin prolonged progression-free and overall survival.
Publisher
Massachusetts Medical Society
Subject
/ Aged
/ Antibodies, Monoclonal - adverse effects
/ Antibodies, Monoclonal - therapeutic use
/ Antineoplastic Agents, Immunological - adverse effects
/ Antineoplastic Agents, Immunological - therapeutic use
/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use
/ Cell Adhesion Molecules - antagonists & inhibitors
/ Female
/ Humans
/ Male
/ Patients
/ Platinum
/ Programmed Cell Death 1 Ligand 2 Protein - antagonists & inhibitors
/ Programmed Cell Death 1 Receptor - antagonists & inhibitors
/ Urologic Neoplasms - drug therapy
/ Urologic Neoplasms - mortality
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