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Fitness compatibility and dengue virus Inhibition in a Bangladeshi strain of Aedes aegypti infected with the Wolbachia strain wAlbB
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Fitness compatibility and dengue virus Inhibition in a Bangladeshi strain of Aedes aegypti infected with the Wolbachia strain wAlbB
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Journal Article
Fitness compatibility and dengue virus Inhibition in a Bangladeshi strain of Aedes aegypti infected with the Wolbachia strain wAlbB
2025
Overview
Dengue cases in Bangladesh have surged in recent years. The existing insecticide-based control program is challenged by issues of insufficient household coverage and high levels of insecticide resistance in the primary dengue virus (DENV) vector,
Aedes aegypti.
A more sustainable, effective alternative could be the implementation of a
Wolbachia
-mediated disease management strategy. Hence, we created and characterised a
Wolbachia
-infected
Ae. aegypti
strain with a Dhaka wild-type genetic background, and compared its reproductive compatibility, maternal inheritance, fitness, and virus-blocking ability to the parental strains (Dhaka wild-type and
w
AlbB2-F4). The new
Ae. aegypti
strain
w
AlbB2-Dhaka demonstrated complete cytoplasmic incompatibility with the wild-type and complete maternal transmission, retaining levels of pyrethroid resistance of the Dhaka wild-type. No significant fitness costs were detected during laboratory comparison. Compared to the wild-type,
w
AlbB2-Dhaka mosquitoes demonstrated a significantly reduced genome copies of DENV in the bodies (44.4%,
p
= 0.0034); a two-fold reduction in dissemination to legs and wings (47.6%,
p
< 0.0001); and > 13-fold reduction of DENV in saliva expectorates (proxy of transmission potential) (92.7%,
p
< 0.0001) 14 days after ingesting dengue-infected blood. Our work indicates that the
w
AlbB2-Dhaka strain could be used for
Ae. aegypti
suppression or replacement strategies for dengue management in Bangladesh.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
