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Adipocyte RNA-binding protein CELF1 promotes beiging of white fat through stabilizing Dio2 mRNA
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Adipocyte RNA-binding protein CELF1 promotes beiging of white fat through stabilizing Dio2 mRNA
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Adipocyte RNA-binding protein CELF1 promotes beiging of white fat through stabilizing Dio2 mRNA
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Journal Article
Adipocyte RNA-binding protein CELF1 promotes beiging of white fat through stabilizing Dio2 mRNA
2025
Overview
RNA-binding proteins (RBPs) regulate diverse post-transcriptional processes and play roles in adipocyte development; however, their role in white fat beiging remains unclear. Here we identify CUG-BP Elav-like family member 1 (CELF1) as a key RBP promoting beiging of inguinal white adipose tissue in response to cold. Adipocyte-specific
Celf1
deficiency impairs cold-induced thermogenic gene expression and reduces energy expenditure. Mechanistically, CELF1 binds to the 3′UTR of
Dio2
mRNA and enhances its stability, promoting local triiodothyronine (T3) production. Notably,
CELF1
expression is significantly reduced in subcutaneous fat of individuals with obesity and negatively correlates with BMI. CELF1 enhances isoproterenol-induced beige adipocyte activation and mitochondrial respiration in vitro, and
Celf1
overexpression ameliorates diet-induced obesity and metabolic dysfunction. Hence, our study identifies CELF1 as a physiological regulator of metabolic stress in activating thermogenesis and promoting energy expenditure at the post-transcriptional level, highlighting its potential as a therapeutic target for obesity and metabolic diseases.
This study identifies CELF1 as a key regulator of fat metabolism. CELF1 promotes beiging and thermogenesis of white fat by stabilizing
Dio2
mRNA. It is reduced in obesity, and its overexpression counters diet-induced metabolic dysfunction.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/89
/ 3' Untranslated Regions - genetics
/ 38/77
/ 38/88
/ 38/90
/ 38/91
/ Adipocytes, Beige - metabolism
/ Adipose Tissue, White - metabolism
/ Animals
/ Body fat
/ Cold
/ Diet
/ Energy
/ Energy Metabolism - genetics
/ Female
/ Humanities and Social Sciences
/ Humans
/ Iodide Peroxidase - genetics
/ Iodide Peroxidase - metabolism
/ Iodothyronine Deiodinase Type II
/ Male
/ Mice
/ Obesity
/ Proteins
/ RNA
/ Science
