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Tick salivary proteins metalloprotease and allergen-like p23 are associated with response to glycan α-Gal and mycobacterium infection
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Tick salivary proteins metalloprotease and allergen-like p23 are associated with response to glycan α-Gal and mycobacterium infection
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Journal Article
Tick salivary proteins metalloprotease and allergen-like p23 are associated with response to glycan α-Gal and mycobacterium infection
2025
Overview
The alpha-Gal syndrome (AGS) evolved as a catastrophic selection associated with anti-α-Gal IgM/IgG protective response against pathogen infection and tick-borne food allergy caused by IgE-type antibodies against this glycan present in glycoproteins and glycolipids from mammalian meat and derived products. The immune response to α-Gal is modulated by tick salivary proteins with and without α-Gal modifications in combination with tick saliva non-protein fraction. Herein, we characterized the role of tick salivary proteins, metalloprotease and allergen-like p23 in AGS and protection against tuberculosis in the AGS zebrafish animal model. Metalloprotease and p23 are involved in allergic reactions after mammalian meat consumption through upregulation of pro-inflammatory protein-coding genes
prkdc
,
tlr2
,
tnfα
and
il1b
. Challenge with
Mycobacterium marinum
activated Th1-mediated immune protective response with reduced pathogen infection, ameliorating Th2-associated allergic reactions associated with AGS. These results highlight molecular mechanisms modulated by tick proteins in response to α-Gal and provide insights to reduce AGS impact on human health.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 692/420
/ 692/699
/ Allergy
/ Animals
/ Food Hypersensitivity - immunology
/ Humanities and Social Sciences
/ Humans
/ Mammals
/ Meat
/ Metalloproteases - immunology
/ Metalloproteases - metabolism
/ Mycobacterium marinum - immunology
/ Polysaccharides - immunology
/ Proteins
/ Saliva
/ Salivary Proteins and Peptides - immunology
/ Salivary Proteins and Peptides - metabolism
/ Science
/ Tick
