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Stable hippocampal correlates of high episodic memory function across adulthood
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Stable hippocampal correlates of high episodic memory function across adulthood
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Journal Article
Stable hippocampal correlates of high episodic memory function across adulthood
2025
Overview
Some older adults show high episodic memory performance compared to same-age peers. It is not known whether their high function is caused by special brain features in aging, or whether superior memory has the same brain foundation throughout adult life. To address this, we measured hippocampal volume and atrophy, microstructural integrity by diffusion tensor imaging, and activity during an episodic memory encoding and retrieval task in cognitively healthy adults (
n
= 277, age 20.1–81.5 years). Atrophy was quantified by repeated MRIs (2–7 examinations, mean max follow-up time 9.3 years). Superior memory was associated with higher retrieval activity in the anterior hippocampus and less hippocampal atrophy. There were no significant age-interactions, suggesting stable correlates of superior memory function. Age-memory performance curves across the full age-range were similar for participants with high memory performance compared to those with normal and low performance. These trajectories were based on cross-sectional data but did not indicate preserved memory among the superior functioning older adults. In conclusion, the results confirm that aspects of hippocampal structure and function are related to superior memory, without evidence to suggest that the best performing older adults are characterized by special hippocampal features compared to their younger counterparts.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/477
/ Adult
/ Aged
/ Aging
/ Atrophy
/ Female
/ Hippocampus - diagnostic imaging
/ Humanities and Social Sciences
/ Humans
/ Male
/ Memory
/ Science
