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Decreased IgD- CD27- double negative B cells in Sjögren’s disease correlated with disease activity index
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Decreased IgD- CD27- double negative B cells in Sjögren’s disease correlated with disease activity index
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Journal Article
Decreased IgD- CD27- double negative B cells in Sjögren’s disease correlated with disease activity index
2025
Overview
Double negative (DN) B cells, defined as CD27-IgD- B cells, are increased in older healthy individuals as well as in patients with certain diseases. However, the relationship between DN B cells and Sjögren’s disease (SjD) in newly diagnosed patients remains unclear. Seventy SjD patients and thirty-six healthy controls (HCs) were recruited in this study. Peripheral blood B cell subsets were analyzed using flow cytometry. The percentage and absolute count of DN B cells were significantly lower in SjD patients compared to HCs (
p
= 0.000 and
p
= 0.007, respectively). Patients with medium to high disease activity, defined by an EULAR Sjögren Syndrome Disease Activity Index (ESSDAI) score ≥ 5, exhibited lower DN B cell levels compared to those with low disease activity (ESSDAI score < 5,
p
= 0.029 and
p
= 0.000, respectively). Moreover, lower DN B cell percentages were associated with glandular involvement (
p
= 0.039) and neutropenia (
p
= 0.034). Regression analysis revealed a negative correlation between DN B cells and SjD disease activity (B=-0.240, 95% CI:-0.468 to -0.013,
p
= 0.039). Additionally, DN B cells showed weak negative correlation with the percentage of total B cells (
r
=-0.266,
p
= 0.026). This study demonstrates that DN B cells are decreased in SjD, particularly in patients with glandular involvement and high disease activity. Moreover, the inverse correlation between DN B cells and total B cells suggested that DN B cells may play a role in the pathogenesis of SjD.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Adult
/ Aged
/ Anemia
/ B-Lymphocyte Subsets - immunology
/ B-Lymphocyte Subsets - metabolism
/ Blood
/ Disease
/ DN b
/ ESSDAI
/ Female
/ Humanities and Social Sciences
/ Humans
/ Immunoglobulin D - metabolism
/ Male
/ Science
/ Sjogren's Syndrome - immunology
/ Sjogren's Syndrome - pathology
/ Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism
