Asset Details
Do you wish to reserve the book?
Food and water intake are regulated by distinct central amygdala circuits revealed using intersectional genetics
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Food and water intake are regulated by distinct central amygdala circuits revealed using intersectional genetics
Do you wish to request the book?
Food and water intake are regulated by distinct central amygdala circuits revealed using intersectional genetics
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Food and water intake are regulated by distinct central amygdala circuits revealed using intersectional genetics
2025
Overview
The central amygdala (CeA) plays a crucial role in defensive and appetitive behaviours. It contains genetically defined GABAergic neuron subpopulations distributed over three anatomical subregions, capsular (CeC), lateral (CeL), and medial (CeM). The roles that these molecularly- and anatomically-defined CeA neurons play in appetitive behavior remain unclear. Using intersectional genetics in mice, we found that neurons driving food or water consumption are confined to the CeM. Separate CeM subpopulations exist for water only versus water or food consumption. In vivo calcium imaging revealed that CeM
Htr2a
neurons promoting feeding are responsive towards appetitive cues with little regard for their physical attributes. CeM
Sst
neurons involved in drinking are sensitive to the physical properties of salient stimuli. Both CeM subtypes receive inhibitory input from CeL and send projections to the parabrachial nucleus to promote appetitive behavior. These results suggest that distinct CeM microcircuits evaluate liquid and solid appetitive stimuli to drive the appropriate behavioral responses.
How the numerous neuron subpopulations in the lateral (CeL) and medial (CeM) subdivisions of the central amygdala regulate appetitive behavior is poorly understood. Here, the authors report that appetitive neurons are confined to the CeM with separate subpopulations driving water only, versus water or food consumption.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/10
/ 14/19
/ 14/35
/ 64
/ 64/60
/ Amygdala
/ Animals
/ Appetitive Behavior - physiology
/ Central Amygdaloid Nucleus - cytology
/ Central Amygdaloid Nucleus - metabolism
/ Central Amygdaloid Nucleus - physiology
/ Feeding Behavior - physiology
/ Female
/ Food
/ GABAergic Neurons - metabolism
/ GABAergic Neurons - physiology
/ Genetics
/ Humanities and Social Sciences
/ Male
/ Mice
/ Neurons
/ Parabrachial Nucleus - physiology
/ Science
/ Stimuli
