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Distinct echinocandin responses of Candida albicans and Candida auris cell walls revealed by solid-state NMR
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Distinct echinocandin responses of Candida albicans and Candida auris cell walls revealed by solid-state NMR
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Journal Article
Distinct echinocandin responses of Candida albicans and Candida auris cell walls revealed by solid-state NMR
2025
Overview
Invasive candidiasis affects 1.6 million people annually, with high mortality among immunocompromised and hospitalized patients. Echinocandins are frontline antifungals, but rising resistance limits their efficacy. Here, we show that
Candida albicans
and multidrug-resistant
Candida auris
share a conserved cell wall architecture yet differ markedly in their adaptive responses to echinocandins. Solid-state NMR reveals that both species possess a rigid inner layer of tightly associated chitin microfibrils and β−1,3-glucans, supported by a flexible matrix of β−1,6-glucans and additional β−1,3-glucans. Outer mannan fibrils rely on α−1,2-linked sidechains to maintain contact with the inner wall. In both species, caspofungin rigidifies β−1,6-glucans and mannan sidechains and reduces water permeability during β−1,3-glucan depletion; however,
C. albicans
undergoes wall thickening and alterations in chitin and glucan dynamics, whereas
C. auris
maintains integrity through β−1,6-glucan upregulation. Deletion of
KRE6a
, which encodes β−1,6-glucan synthase, reduces echinocandin susceptibility in
C. auris
, further highlighting β−1,6-glucan’s critical role in adaptive remodeling.
The prevalent fungal pathogen,
Candida albicans
, and the emerging multidrug-resistant superfungus,
Candida auris
, share the same initial cell wall architecture but remodel it differently in response to echinocandin-induced antifungal stress.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Antifungal Agents - pharmacology
/ Candida albicans - drug effects
/ Candida albicans - metabolism
/ Candida albicans - ultrastructure
/ Candida auris - drug effects
/ Chitin
/ COVID-19
/ Echinocandins - pharmacology
/ Fibrils
/ Fungal Proteins - metabolism
/ Glucan
/ Glucans
/ Glucosyltransferases - genetics
/ Glucosyltransferases - metabolism
/ Humanities and Social Sciences
/ Magnetic Resonance Spectroscopy - methods
/ Mannan
/ Multidrug resistant organisms
/ NMR
/ Science
/ Yeast
