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Tranexamic Acid to Prevent Obstetrical Hemorrhage after Cesarean Delivery

by Gyamfi-Bannerman, Cynthia , Bailit, Jennifer L. , Thorp, John M. , Macones, George A. , Metz, Torri D. , Rouse, Dwight J. , Dalton, Wendy , Grobman, William A. , Simhan, Hyagriv N. , Clifton, Rebecca G. , Tita, Alan T.N. , Weiner, Steven J. , Parry, Samuel , Rood, Kara , Pacheco, Luis D. , Saade, George R. , Chauhan, Suneet P. , Longo, Monica , Salazar, Ashley

in Acids / Antifibrinolytic agents / Antifibrinolytic Agents - adverse effects / Antifibrinolytic Agents - therapeutic use / Bleeding / Blood Loss, Surgical - mortality / Blood Loss, Surgical - prevention & control / Blood products / Blood Transfusion / Blood transfusions / Cesarean section / Cesarean Section - adverse effects / Chemoprevention / Child / Childbirth & labor / Complications of Pregnancy / Emergency medical care / FDA approval / Female / Gynecology / Gynecology General / Hemoglobin / Hemoglobins - analysis / Hemorrhage / Hormones / Hospitals / Humans / Informed consent / Maternal Death / Maternal mortality / Obstetrics / Placebos / Postpartum / Postpartum Hemorrhage - blood / Postpartum Hemorrhage - etiology / Postpartum Hemorrhage - mortality / Postpartum Hemorrhage - prevention & control / Pregnancy / Statistical analysis / Thromboembolism / Tranexamic Acid - adverse effects / Tranexamic Acid - therapeutic use

2023

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2023

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2023

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Journal Article

Tranexamic Acid to Prevent Obstetrical Hemorrhage after Cesarean Delivery

Gyamfi-Bannerman, Cynthia,

Bailit, Jennifer L.,

Thorp, John M.,

Macones, George A.,

Metz, Torri D.,

Rouse, Dwight J.,

Dalton, Wendy,

Grobman, William A.,

Simhan, Hyagriv N.,

Clifton, Rebecca G.,

Tita, Alan T.N.,

Weiner, Steven J.,

Parry, Samuel,

Rood, Kara,

Pacheco, Luis D.,

Saade, George R.,

Chauhan, Suneet P.,

Longo, Monica,

Salazar, Ashley

2023

Overview

In a placebo-controlled trial involving patients undergoing cesarean delivery, prophylactic use of tranexamic acid did not lead to a significantly lower risk of a composite outcome of maternal death or blood transfusion.

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Publisher

Massachusetts Medical Society

Subject

Acids

/ Antifibrinolytic agents

/ Antifibrinolytic Agents - adverse effects

/ Antifibrinolytic Agents - therapeutic use

/ Bleeding

/ Blood Loss, Surgical - mortality

/ Blood Loss, Surgical - prevention & control