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Bax Inhibitor 1 in apoptosis and disease
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Journal Article
Bax Inhibitor 1 in apoptosis and disease
2011
Overview
Bax inhibitor 1 (BI-1) was originally discovered as an inhibitor of Bax-induced apoptosis; this review highlights the fundamental importance of BI-1 in a wider context, including in tissue homeostasis and as a regulator of cellular stress. BI-1 has been shown to interact with a broad range of partners to inhibit many facets of apoptosis, such as reactive oxygen species production, cytosolic acidification and calcium levels as well as endoplasmic reticulum stress signalling pathways. BI-1's anti-apoptotic action initially enables the cell to adapt to stress, although if the stress is prolonged or severe the actions of BI-1 may promote apoptosis. This almost universal anti-apoptotic capacity has been shown to be manipulated during infection with enteropathogenic and enterohaemorrhagic
Escherichia coli
inhibiting host cell death through direct interaction between their effector NleH and BI-1. In addition, BI-1 activity is important in a large number of cancers, promoting metastasis by modulating actin dynamics, a process dependent upon the BI-1 C-terminus and BI-1:actin interaction. Manipulation of BI-1 therefore has the potential for significant therapeutic benefit in a wide range of human diseases.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Actin
/ Apoptosis Regulatory Proteins - genetics
/ Apoptosis Regulatory Proteins - metabolism
/ Biological and medical sciences
/ Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
/ Fundamental and applied biological sciences. Psychology
/ Gynecology. Andrology. Obstetrics
/ Humans
/ Medicine
/ Membrane Proteins - genetics
/ Membrane Proteins - metabolism
/ Molecular and cellular biology
/ Oncology
/ Reactive Oxygen Species - metabolism
/ review
/ Sequence Homology, Amino Acid
/ Tumors
