Journal Article

Coffee polyphenols modulate whole-body substrate oxidation and suppress postprandial hyperglycaemia, hyperinsulinaemia and hyperlipidaemia

Suzuki, Yasuto, Yokoi, Yuka, Hase, Tadashi, Murase, Takatoshi, Misawa, Koichi, Ominami, Hideo, Shibuya, Yusuke

2012

Overview

Postprandial energy metabolism, including postprandial hyperglycaemia, hyperinsulinaemia and hyperlipidaemia, is related to the risk for developing obesity and CVD. In the present study, we examined the effects of polyphenols purified from coffee (coffee polyphenols (CPP)) on postprandial carbohydrate and lipid metabolism, and whole-body substrate oxidation in C57BL/6J mice. In mice that co-ingested CPP with a lipid–carbohydrate (sucrose or starch)-mixed emulsion, the respiratory quotient determined by indirect calorimetry was significantly lower than that in control mice, whereas there was no difference in VO2 (energy expenditure), indicating that CPP modulates postprandial energy partitioning. CPP also suppressed postprandial increases in plasma glucose, insulin, glucose-dependent insulinotropic polypeptide and TAG levels. Inhibition experiments on digestive enzymes revealed that CPP inhibits maltase and sucrase, and, to a lesser extent, pancreatic lipase in a concentration-dependent manner. Among the nine kinds of polyphenols (caffeoyl quinic acids (CQA), di-CQA, feruloyl quinic acids (FQA)) contained in CPP, di-CQA showed more potent inhibitory activity than CQA or FQA on these digestive enzymes, suggesting a predominant role of di-CQA in the regulation of postprandial energy metabolism. These results suggest that CPP modulates whole-body substrate oxidation by suppressing postprandial hyperglycaemia and hyperinsulinaemia, and these effects are mediated by inhibiting digestive enzymes.

• Publisher: Cambridge University Press
• Subject: acids / alpha-glucosidase / Animals / Biological and medical sciences / blood glucose / Blood Glucose - metabolism / Calorimetry / Cell Respiration / Coffea - chemistry / Coffee / Coffee - chemistry / Dietary Carbohydrates - metabolism / Dietary Fats - metabolism / Digestion - drug effects / Dose-Response Relationship, Drug / emulsions / energy expenditure / Energy Metabolism / Feeding. Feeding behavior / Fundamental and applied biological sciences. Psychology / gastric inhibitory polypeptide / Hyperglycemia / Hyperglycemia - complications / Hyperglycemia - drug therapy / Hyperglycemia - metabolism / hyperinsulinemia / Hyperinsulinism - complications / Hyperinsulinism - drug therapy / Hyperinsulinism - metabolism / hyperlipidemia / Hyperlipidemias - complications / Hyperlipidemias - drug therapy / Hyperlipidemias - metabolism / insulin / Insulin - blood / lipid metabolism / Male / Metabolic Diseases - complications / Metabolic Diseases - drug therapy / Metabolic Diseases - metabolism / Metabolism / Metabolism and Metabolic Studies / Mice / Mice, Inbred C57BL / obesity / Obesity - etiology / Obesity - metabolism / Obesity - prevention & control / Oxidation / Oxidation-Reduction / Oxygen Consumption / Phytotherapy / Plant Extracts - pharmacology / Plant Extracts - therapeutic use / Polyphenols / Polyphenols - pharmacology / Polyphenols - therapeutic use / Postprandial Period / Quinic Acid - analogs & derivatives / Quinic Acid - pharmacology / Quinic Acid - therapeutic use / respiratory quotient / risk / Rodents / starch / sucrose / sucrose alpha-glucosidase / triacylglycerol lipase / Triglycerides - blood / Vertebrates: anatomy and physiology, studies on body, several organs or systems