Asset Details
Do you wish to reserve the book?
Relationship of orthostatic blood pressure to white matter hyperintensities and subcortical volumes in late-life depression
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Relationship of orthostatic blood pressure to white matter hyperintensities and subcortical volumes in late-life depression
Do you wish to request the book?
Relationship of orthostatic blood pressure to white matter hyperintensities and subcortical volumes in late-life depression
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Relationship of orthostatic blood pressure to white matter hyperintensities and subcortical volumes in late-life depression
2011
Overview
Structural brain abnormalities are associated with late-life major depression, with numerous studies reporting increased white matter hyperintensities (WMH) and reduced cortical/subcortical grey matter volumes. There is strong evidence linking vascular disease to WMH, but limited evidence on its association with subcortical volumes.
To investigate the relationship of orthostatic blood pressure changes to WMH and subcortical grey matter volumes in late-life depression.
Thirty-eight people with depression and a similarly aged comparison group (n = 30) underwent fluid attenuated inversion recovery (FLAIR) and T(1)-weighted magnetic resonance imaging as well as systematic orthostatic blood pressure assessments. Volumetric estimates of WMH and subcortical grey matter were obtained for each participant and the relationship to blood pressure drop on active stand was examined.
An association between orthostatic systolic blood pressure drop and WMH volumes in temporal and parietal regions was found in the depression group (age-corrected partial correlation r' = 0.31-0.35, P<0.05). Subcortical volumes were not related to blood pressure changes or WMH volumes in either group.
We found evidence for an association between the degree of orthostatic systolic blood pressure drop and WMH volume in the depression group. Since blood pressure drops lead to WMH in animals our findings suggest systolic blood pressure drops may be a factor contributing to these lesions in late-life depression.
Publisher
Cambridge University Press
Subject
/ Aged
/ Aging
/ Animals
/ Antihypertensive Agents - therapeutic use
/ Atrophy
/ Blood Pressure Determination - methods
/ Brain
/ Cortex
/ Dementia
/ Depressive Disorder, Major - epidemiology
/ Depressive Disorder, Major - pathology
/ Depressive Disorder, Major - physiopathology
/ Drugs
/ Female
/ Humans
/ Hypotension, Orthostatic - epidemiology
/ Hypotension, Orthostatic - pathology
/ Hypotension, Orthostatic - physiopathology
/ Image Processing, Computer-Assisted
/ Lesions
/ Life
/ Magnetic Resonance Imaging - methods
/ Male
/ NMR
/ Parietal Lobe - blood supply
/ Psychiatric Status Rating Scales
/ Stroke
