Asset Details
Do you wish to reserve the book?
Concept and location neurons in the human brain provide the ‘what’ and ‘where’ in memory formation
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Concept and location neurons in the human brain provide the ‘what’ and ‘where’ in memory formation
Do you wish to request the book?
Concept and location neurons in the human brain provide the ‘what’ and ‘where’ in memory formation
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Concept and location neurons in the human brain provide the ‘what’ and ‘where’ in memory formation
2024
Overview
Our brains create new memories by capturing the ‘who/what’, ‘where’ and ‘when’ of everyday experiences. On a neuronal level, mechanisms facilitating a successful transfer into episodic memory are still unclear. We investigated this by measuring single neuron activity in the human medial temporal lobe during encoding of item-location associations. While previous research has found predictive effects in population activity in human MTL structures, we could attribute such effects to two specialized sub-groups of neurons: concept cells in the hippocampus, amygdala and entorhinal cortex (EC), and a second group of parahippocampal location-selective neurons. In both item- and location-selective populations, firing rates were significantly higher during successfully encoded trials. These findings are in line with theories of hippocampal indexing, since selective index neurons may act as pointers to neocortical representations. Overall, activation of distinct populations of neurons could directly support the connection of the ‘what’ and ‘where’ of episodic memory.
Whether specialized neuronal firing in the human MTL predicts successful memory encoding remains unknown. Here, the authors find this to be the case for two distinct populations of single neurons responding to items and locations, respectively.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
