Asset Details
Do you wish to reserve the book?
Induction of resident memory T cells enhances the efficacy of cancer vaccine
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Induction of resident memory T cells enhances the efficacy of cancer vaccine
Do you wish to request the book?
Induction of resident memory T cells enhances the efficacy of cancer vaccine
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Induction of resident memory T cells enhances the efficacy of cancer vaccine
2017
Overview
Tissue-resident memory T cells (Trm) represent a new subset of long-lived memory T cells that remain in tissue and do not recirculate. Although they are considered as early immune effectors in infectious diseases, their role in cancer immunosurveillance remains unknown. In a preclinical model of head and neck cancer, we show that intranasal vaccination with a mucosal vector, the B subunit of Shiga toxin, induces local Trm and inhibits tumour growth. As Trm do not recirculate, we demonstrate their crucial role in the efficacy of cancer vaccine with parabiosis experiments. Blockade of TFGβ decreases the induction of Trm after mucosal vaccine immunization, resulting in the lower efficacy of cancer vaccine. In order to extrapolate this role of Trm in humans, we show that the number of Trm correlates with a better overall survival in lung cancer in multivariate analysis. The induction of Trm may represent a new surrogate biomarker for the efficacy of cancer vaccine. This study also argues for the development of vaccine strategies designed to elicit them.
Resident memory T cells (Trm) are memory T cells that remain in tissue. Here, the authors show that induction of Trm cells is required for control of tumour growth following mucosal vaccination in mice bearing head and neck cancer and that Trm cells in human lung cancer correlates with a better survival.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/51
/ 14/1
/ 38/39
/ Animals
/ Biomarkers, Tumor - metabolism
/ Cancer
/ Cancer Vaccines - administration & dosage
/ Cancer Vaccines - immunology
/ Cancer Vaccines - therapeutic use
/ Carcinoma, Non-Small-Cell Lung - immunology
/ Carcinoma, Non-Small-Cell Lung - metabolism
/ Carcinoma, Non-Small-Cell Lung - therapy
/ CD8-Positive T-Lymphocytes - immunology
/ Female
/ Head and Neck Neoplasms - immunology
/ Head and Neck Neoplasms - metabolism
/ Head and Neck Neoplasms - pathology
/ Head and Neck Neoplasms - therapy
/ Humanities and Social Sciences
/ Humans
/ Mucous Membrane - immunology
/ Science
/ Toxins
/ Vaccines
