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Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss
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Journal Article
Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss
2015
Overview
Immunglobulin G (IgG) sialylation represents a key checkpoint that determines the engagement of pro- or anti-inflammatory Fcγ receptors (FcγR) and the direction of the immune response. Whether IgG sialylation influences osteoclast differentiation and subsequently bone architecture has not been determined yet, but may represent an important link between immune activation and bone loss. Here we demonstrate that desialylated, but not sialylated, immune complexes enhance osteoclastogenesis
in vitro
and
in vivo
. Furthermore, we find that the Fc sialylation state of random IgG and specific IgG autoantibodies determines bone architecture in patients with rheumatoid arthritis. In accordance with these findings, mice treated with the sialic acid precursor N-acetylmannosamine (ManNAc), which results in increased IgG sialylation, are less susceptible to inflammatory bone loss. Taken together, our findings provide a novel mechanism by which immune responses influence the human skeleton and an innovative treatment approach to inhibit immune-mediated bone loss.
The IgG sugar moiety modulates the binding of immune complexes to their Fcγ receptors resulting in pro- or anti-inflammatory response. This study shows that IgG sialylation also affects osteoclastogenesis and bone mass in mice and humans, identifying a new link between bone and the immune system.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Pub. Group
Subject
/ 64/60
/ 692/308
/ 82/51
/ 82/58
/ Acids
/ Animals
/ Antigens
/ Arthritis, Experimental - diagnostic imaging
/ Arthritis, Experimental - immunology
/ Arthritis, Experimental - metabolism
/ Arthritis, Rheumatoid - immunology
/ Arthritis, Rheumatoid - metabolism
/ Bone and Bones - diagnostic imaging
/ Bone Resorption - diagnostic imaging
/ Bone Resorption - immunology
/ Bone Resorption - metabolism
/ Cell Differentiation - immunology
/ Female
/ Humanities and Social Sciences
/ Humans
/ Immunoglobulin Fc Fragments - metabolism
/ Immunoglobulin G - immunology
/ Immunoglobulin G - metabolism
/ Male
/ Mice
/ N-Acetylneuraminic Acid - metabolism
/ Proteins
/ Reverse Transcriptase Polymerase Chain Reaction
/ Science
