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New Hosts of The Lassa Virus

by Günther, Stephan , Fichet-Calvet, Elisabeth , Rieger, Toni , Cadar, Daniel , Fasogbon, Samuel , Obadare, Adeoba , Schmidt-Chanasit, Jonas , Jérôme, Hanna , Oyeyiola, Akinlabi , Bockholt, Sabrina , Igbahenah, Felix , Garigliany, Mutien , Lorenzen, Stephan , Olayemi, Ayodeji , Omilabu, Sunday , Magassouba, N’Faly , Ortsega, Daniel , Igbokwe, Joseph , Fichet, Jean-Nicolas , Kourouma, Fode

in 45/29 / 45/77 / 45/91 / 631/158/1469 / 631/181/757 / 631/326/596/2564 / Africa / Amino acids / Animals / Fever / Genes / Genomes / Genotype / Guinea / Hemorrhagic fever / Host Specificity / Human health sciences / Humanities and Social Sciences / Immunologie & maladie infectieuse / Immunology & infectious disease / L gene / Laboratories / Lassa virus - classification / Lassa virus - genetics / Lassa virus - isolation & purification / Lassa virus - physiology / Matrix protein / Mice / multidisciplinary / Murinae - virology / Nigeria / Phylogenetics / Phylogeny / Rodents / S gene / Science / Science (multidisciplinary) / Sciences de la santé humaine / Sequence Analysis, DNA / Small mammals / Strains (organisms) / Veterinary medicine

2016

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2016

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2016

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Journal Article

New Hosts of The Lassa Virus

Günther, Stephan,

Fichet-Calvet, Elisabeth,

Rieger, Toni,

Cadar, Daniel,

Fasogbon, Samuel,

Obadare, Adeoba,

Schmidt-Chanasit, Jonas,

Jérôme, Hanna,

Oyeyiola, Akinlabi,

Bockholt, Sabrina,

Igbahenah, Felix,

Garigliany, Mutien,

Lorenzen, Stephan,

Olayemi, Ayodeji,

Omilabu, Sunday,

Magassouba, N’Faly,

Ortsega, Daniel,

Igbokwe, Joseph,

Fichet, Jean-Nicolas,

Kourouma, Fode

2016

Overview

Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several thousand people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys natalensis , has been assumed to be the sole host of LASV. We found evidence that LASV is also hosted by other rodent species: the African wood mouse Hylomyscus pamfi in Nigeria, and the Guinea multimammate mouse Mastomys erythroleucus in both Nigeria and Guinea. Virus strains from these animals were isolated in the BSL-4 laboratory and fully sequenced. Phylogenetic analyses of viral genes coding for glycoprotein, nucleoprotein, polymerase and matrix protein show that Lassa strains detected in M. erythroleucus belong to lineages III and IV. The strain from H. pamfi clusters close to lineage I (for S gene) and between II & III (for L gene). Discovery of new rodent hosts has implications for LASV evolution and its spread into new areas within West Africa.

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Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

45/29

/ 45/77

/ 45/91

/ 631/158/1469

/ 631/181/757

/ 631/326/596/2564

/ Africa